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Table 1 Targeted next-generation sequencing of both tumors showing the same results with an identical activating mutation in the PIK3CA gene exon 20

From: Bile duct carcinoma recurrence in the papillary region in a long-term survivor of hilar cholangiocarcinoma: a case report

Gene Exon Codon Mutation Interpretation
BRAF 15 582–612 Wildtype  
DDR2 3–18 1–342, 351–395, 432–586, 620–856 Wildtype  
ERBB2 8, 19–21 302–321, 761–881 Wildtype  
HRAS 2–4 1–35, 41–82, 105–150 Wildtype  
KEAP1 2–6 1–34, 37–122, 127–437, 443–625 Wildtype  
KRAS 2–4 4–66, 111–150 Wildtype  
NFE2L2 2 16–104 Wildtype  
NRAS 2–4 1–32, 45–83, 110–150 Wildtype  
PIK3CA 1, 4, 7, 9, 20 66–117, 312–350, 418–435, 521–554, 980–1069 EX20: c.3140A>G p.H1047R activating
PTEN 1–9 1–34, 39–267, 275–333, 343–366 Wildtype  
RHOA 2, 3 3–89 Wildtype  
TP53 5–9 133–260, 263–331 Wildtype