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Table 1 Targeted next-generation sequencing of both tumors showing the same results with an identical activating mutation in the PIK3CA gene exon 20

From: Bile duct carcinoma recurrence in the papillary region in a long-term survivor of hilar cholangiocarcinoma: a case report

Gene

Exon

Codon

Mutation

Interpretation

BRAF

15

582–612

Wildtype

 

DDR2

3–18

1–342, 351–395, 432–586, 620–856

Wildtype

 

ERBB2

8, 19–21

302–321, 761–881

Wildtype

 

HRAS

2–4

1–35, 41–82, 105–150

Wildtype

 

KEAP1

2–6

1–34, 37–122, 127–437, 443–625

Wildtype

 

KRAS

2–4

4–66, 111–150

Wildtype

 

NFE2L2

2

16–104

Wildtype

 

NRAS

2–4

1–32, 45–83, 110–150

Wildtype

 

PIK3CA

1, 4, 7, 9, 20

66–117, 312–350, 418–435, 521–554, 980–1069

EX20: c.3140A>G p.H1047R

activating

PTEN

1–9

1–34, 39–267, 275–333, 343–366

Wildtype

 

RHOA

2, 3

3–89

Wildtype

 

TP53

5–9

133–260, 263–331

Wildtype

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