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Fig. 3 | Journal of Medical Case Reports

Fig. 3

From: The effects of liraglutide on both hypereosinophilic insulin allergy and the characteristics of anti-insulin antibodies in type 2 diabetes mellitus: a case report

Fig. 3

Scatchard plot analysis showing changes in the characteristics of anti-insulin immunoglobulin G antibodies before and after treatment with liraglutide. a The Scatchard plot analysis before the treatment of liraglutide. The binding capacity (10−8 M) of 882 (R1) and affinity constant (108 M−1) of 0.000582 (K1) for high affinity sites and the binding capacity (10−8 M) of 4830 (R2) and affinity constant (108 M−1) of 0.0000190 (K2) for low affinity sites are shown. b The Scatchard plot analysis approximately 1 year after starting liraglutide. The binding capacity (10−8 M) of 70.6 (R1) and affinity constant (108 M−1) of 0.00203 (K1) for high affinity sites and the binding capacity (10−8 M) of 298 (R2) and affinity constant (108 M−1) of 0.0000704 (K2) for low affinity sites are shown. c It is notable, particularly for high affinity sites, that the binding capacity (10−8 M) has changed from 882 to 70.6 (R1), and that the affinity constant (108 M−1) has changed from 0.000582 to 0.00203 (K1). Therefore, liraglutide appeared to induce a decrease in the binding capacity and an increase in the affinity constant for high affinity sites of anti-insulin immunoglobulin G antibodies

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