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Table 3 Laboratory values

From: Intravascular large B-cell lymphoma associated with silicone breast implant, HLA-DRB1*11:01, and HLA-DQB1*03:01 manifesting as macrophage activation syndrome and with severe neurological symptoms: a case report

Analyte

Reference

Day 1

Day 12

Day 22

Day 29

Leukocyte count (×103/μL)

4.3–11.0

2.9

1.6

4.8

5.9

Polymorphonucleocytes (×103/μL)

1.9–8.0

1.3

1.0

3.7

5.1

Lymphocytes (×103/μL)

1.0–3.7

1.0

0.3

0.5

0.3

Hemoglobin (g/dL)

12–16

9.7

8.2

10.9

9.3

Platelet count (×103/μL)

140–450

151

77

68

58

Triglycerides (mg/dL)

30–150

128

296

301

442

Fibrinogen (mg/dL)

180–500

-

474

94

98

Ferritin (ng/mL)

13–150

309

673

1046

733

sIL-2R(CD25) (kU/L)

223–718

-

13,190

15,730

45,800

sIL-2R/ferritin ratio

<2*

-

20

15

62

Lactate dehydrogenase (U/L)

120–230

265

412

451

454

Aspartate transaminase (IU/L)

<40

13

23

76

59

Alanine transaminase (IU/L)

<40

12

17

59

68

Total bilirubin (mg/dL)

<1.4

0.4

0.3

0.5

2.8

Conjugated bilirubin (mg/dL)

<0.3

0.2

0.2

0.4

2.6

Albumin (g/dL)

3.5–5.2

2.8

2.8

2.1

1.7

Erythrocyte sedimentation rate (mm/h)

<30

81

65

-

-

C-reactive protein (mg/dL)

<0.50

0.62

9.9

16.8

8.2

Lupus anticoagulant panel

 aPTT-low phospholipid

<1.15

 

0.85

  

 DRVVT ratio

<1.10

 

1.3

  

Cerebrospinal fluid

  Cells (/μL)

≤5

 

0

 

4

  Glucose (mg/dL)

50–75

 

60

 

39

  Protein (mg/dL)

15–45

 

282

 

152

  Chloride (mmol/L)

120–132

 

113

 

107

  Lactate (mmol/L)

1.1–2.2

 

2.9

 

6.6

  Link index

<0.7

 

0.5

 

0.5

Widal Wright reaction to

  Salmonella O antigen

≤1:160

 

1:160

 

1:160

  Salmonella H antigen

≤1:160

 

1:2560

 

1:2560

  1. High-resolution human leukocyte antigen (HLA) typing: HLA-A *32:01, HLA-B *40:02, *51:01, HLA-C *02:02,16:02, HLA-DRB1 *11:01,*11:04, HLA-DQB1 *03:01
  2. Negative results: repeated blood cultures; QuantiFERON-TB test, search in blood for plasmodia, Plasmodium antigen, Leishmania immunoglobulin G (immunoblotting), hepatitis C virus antibody, Legionella pneumophila antibody, Mycoplasma pneumoniae antibody, Coxiella burnetii antibody, Bartonella henselae antibody, Brucella antibody, Borrelia burgdorferi antibody, Treponema pallidum antibody, HIV antibody, hepatitis B virus DNA, cytomegalovirus DNA, Epstein-Barr virus DNA, human herpesvirus6 DNA, parvovirus immunoglobulin M; urine cultures; search in urine for Legionella antigen; search in bone marrow aspirate for Leishmania, M. tuberculosis DNA; antinuclear antibodies
  3. Values out of the reference range are in bold; normal routine laboratory values are not listed
  4. *A ratio >2 is observed in most patients with lymphoma-associated hemophagocytic lymphohistiocytosis [50, 51]
  5. aPPT activate partial thromboplastin time, DRVVT dilute Russell’s viper venom time, sIL-2R soluble interleukin-2 receptor