Table 2 2004 Cairo and Bishop criteria for Tumor Lysis Syndrome
Variable | Grade 0 | Grade I | Grade II | Grade III | Grade IV | Grade V |
|---|---|---|---|---|---|---|
Creatinine | None | 1.5 X ULN | ˃1.5–3.0 X ULN | ˃3.0–6.0 X ULN | ˃6.0 X ULN | Death |
Cardiac arrhythmia | None | Intervention not indicated | Nonurgent medical intervention indicated | Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator) | Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock) | Death |
Seizures | None | One brief, generalized seizure; seizure(s) well controlled by anticonvulsants, or infrequent focal motor seizures not interfering with ADL | Seizures in which consciousness is altered; poorly controlled seizure disorder; with breakthrough generalized seizures despite medical intervention | Seizures of any kind which are prolonged, repetitive, or difficult to control (e.g., status epilepticus, intractable epilepsy) | Death |