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Table 1 Reported cases of the use of crizotinib in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

From: Crizotinib in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma in the setting of renal insufficiency: a case report

Study Age Stage (Ann Arbor) ECOG Previous therapy lines Response, in months
Gambacorti Passerini et al. 2014 [11] 26 IIIB 2 CHOP, DHAP, HD-VP16 CR, >40
  19 IVB 3 CHOP, DHAP, BEAM CR, 2
  22 IIB 1 CHOP, VAD, H-CyVAD CR, >35
  20 IIB 2 CHOP, DHAP, BEAM CR, 2
  47 IIIB 2 IEV, CHOP, DHAP CR, >30
  28 IIIBe 2 CHOP, DHAP, miniBEAM CR, 2
  34 IVBe 2 CHOP, ESHAP CR, 3
  38 IVB 4 CHOP, DHAP, VIM CR, 8
  55 IIIB 1 CHOP CR, >21
Ordemann et al. 2013 [12] 29 na na CHOP-21, DHAP, Dexa-BEAM PR, 1
Cleary et al. 2014 [13] 34 na na CHOP, gemcitabine-based therapy, pralatrexate, Mtx, brentuximab CR, 30; allo-SCT at week 13
Conyers et al. 2014 [14] 22 IIIB na CHOP CR, >21; allo-SCT at 2 months
Current case 48 IV 3 CHOP, ICE CR, >29
  1. allo-SCT allogeneic stem cell transplant, BEAM carmustine, etoposide, cytarabine, melphalan, CHOP cyclophosphamide, doxorubicin (adriamycin), vincristine, prednisone, CR complete response, Dexa-BEAM dexamethasone, carmustine, etoposide, cytarabine, melphalan, DHAP dexamethasone, cisplatin, cytarabine, ECOG Eastern Cooperative Group, ESHAP etoposide, methylprednisolone, cytarabine, cisplatin, H-CyVAD alternate regimens of 1) cyclophosphamide, vincristine, doxorubicin (adriamycin), dexamethasone; 2) methotrexate and cytarabine; HD-VP16 high-dose etoposide, ICE ifosfamide, carboplatin, etoposide, IEV Ifosfamide, epirubicin, etoposide, miniBEAM carmustine, etoposide, cytarabine, melphalan, Mtx methotrexate, na not available, PR partial response, VAD vincristine, doxorubicin, high-dose dexamethasone, VIM ifosfamide, mitoxantrone, etoposide