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Table 1 Clinical and histopathological differential diagnosis of traumatic neuroma versus other neurogenic tumors

From: A diffuse traumatic neuroma in the palate: a case report

 

Clinical features

Histopathological features

Traumatic neuroma

Symptomatic (anesthesia, dysesthesia, and pain), solitary

Many nerve bundles, fibrous connective tissue background containing inflammatory cells

Mucosal neuroma

Asymptomatic, typically multiple, associated with multiple endocrine neoplasia type 2B

Many nerve bundles, normal or loose fibrous connective tissue background without inflammatory cells

Neurofibroma

Asymptomatic, solitary, or multiple

Nuclei with wavy or serpiginous prolife, fibrous connective tissue background containing mast cells

Palisading neuroma

Asymptomatic, solitary

Circumscribe, spindle cells showing palisading arrangement

Neurovascular hamartoma

Asymptomatic, solitary

Many nerve bundles containing vessels, fibrous connective tissue background without inflammatory cells