Fig. 1

Representative photomicrographs from the initial resection specimen. a The tumor was relatively well circumscribed, with scattered lymphoid aggregates noted at the edge. b There was extensive fibrosis with scattered inflammatory cells and occasional enlarged cells with vague vacuolation (arrow). c Upon review, some of these atypical cells (arrow) showed cytoplasmic vacuolation raising the possibility of a lipoblast. d Fluorescent in situ hybridization studies demonstrated amplification of MDM2 (red signal) compared to the chromosome 12 centromere probe (green signal). Original magnifications a 20×, b 100×, c 400×, d 1000×