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Table 1 Diagnostic criteria for neoplastic fever

From: Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report

Temperature over 37.8 °C at least once each day

Duration of fever over 2 weeks

Lack of evidence of infection (physical examination, laboratory examinations, imaging studies)

Absence of allergic mechanisms (drug allergy, transfusion reaction, and radiation or chemotherapeutic drug reaction)

Lack of response of fever to an empiric, adequate antibiotic therapy for at least 7 days

Prompt complete lysis of fever by the naproxen test with sustained normal temperature while receiving naproxen