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Fig. 5 | Journal of Medical Case Reports

Fig. 5

From: Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report

Fig. 5

Mechanism of neoplastic fever. Inflammatory cytokines are produced by necrotic tissue or tumor cells, and these factors act on the hypothalamus through prostaglandin E2 induction, thereby by causing fever by raising the set body temperature. Furthermore, tumor necrosis factor-α acts on the liver, producing C-reactive protein and thus increasing the serum C-reactive protein level. CRP C-reactive protein, IL-1 interleukin-1, IL-6 interleukin-6, IL-10 interleukin-10, PGE2 prostaglandin E2, TNF-α tumor necrosis factor-α

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Journal of Medical Case Reports

ISSN: 1752-1947