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Table 1 Clinical characteristics and diagnostic test results of cases 1 to 3

From: Immediate and non-immediate allergic reactions to amoxicillin present a diagnostic dilemma: a case series

Case

Clinical history

Oral challenge

Skin test: Pre-Pen® (benzylpenicilloyl polylysine)

1

8-year-old white girl Treated for uncomplicated pneumoniaa Immediate reaction: seventh day of treatment, 15 minutes after ingestion

Immediate reaction: 20 minutes after ingestion of full dose

N/A

2

2-year-old white boy Treated for uncomplicated otitis mediaa Non-immediate reaction: eighth day of treatment, rash noticed in the morning after he woke up

Non-immediate reaction: 18 hours post-ingestion of full dose

N/A

3

14-month-old Chinese boy Treated for otitis mediaa Non-immediate reaction: third day of treatment, rash noticed after he awoke from sleep, prior to morning dose

Immediate reaction: 15 minutes post-ingestion of initial dose

Positive 8×16 mm (wheal/erythema)

  1. aAll cases were being treated with amoxicillin, weight-based dose. N/A not applicable