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Table 1 Investigation results

From: PRKAR1A-negative familial Cushing’s syndrome: two case reports

Investigations Patient 1 Patient 2 Reference range
Liddle’s test N/A 24-h UFC (predexamethasone) 3923 nmol/L 58–805 nmol/L
24-h UFC (postdexamethasone) 4168 nmol/L
HbA1c (NGSP) 5.1 % 5.1 % <6.5 %
fT4 12.9 pmol/L 16.7 pmol/L 11–23 pmol/L
TSH 0.67 mIU/L 0.72 mIU/L 0.5–5.5 mIU/L
IGF-1 268 ng/ml 282 ng/ml 116–350 ng/ml (patient 1)
193–731 ng/ml (patient 2)
GH 2.3 ng/ml 0.2 ng/ml 0.0–3.0 ng/ml
LH 1.4 IU/L 5.8 IU/L Follicular phase 1.9–12.5 IU/L
Midcycle 8.7–76.3 IU/L
Luteal phase 0.5–16.9 IU/L
Male 1.5–9.3 IU/L
FSH 2.2 IU/L 8.8 IU/L Follicular phase 2.5–10.2 IU/L
Midcycle 3.4–33.4 IU/L
Luteal 1.5–9.1 IU/L
Male 1.4–18.1 IU/L
Testosterone 3.4 nmol/L 13.0 nmol/L Female 0.5–2.6 nmol/L
Male 9.3–23.0 nmol/L
DHEA-S 0.07 μg/dl 0.04 μg/dl Female 0.02–0.30 μg/dl
Male 0.10–0.40 μg/dl
Estradiol 153 pg/ml N/A Follicular phase 20–144 pg/ml
Midcycle 64–357 pg/ml
Luteal phase 56–214 pg/ml
Prolactin 123 mIU/L 127 mIU/L Female 59–619 mIU/L
Male 44–373 mIU/L
Thyroid US Normal Well-defined right thyroid cystic nodule with soft tissue component (1.1 × 1.0 × 1.4 cm), increased peripheral vascularity  
  1. N/A not applicable HbA1c hemoglobin A1c, NGSP National Glycohemoglobin Standardization Program, DHEA-S dehydroepiandrosterone sulfate, US ultrasound, IGF-1 insulin-like growth factor 1, GH growth hormone, LH luteinizing hormone, FSH follicle-stimulating hormone, fT4 free thyroxine, TSH thyroid-stimulating hormone, UFC urinary free cortisol