Table 1 Clinical and pathologic features, diagnosis, treatment, and outcome of peripheral neuroectodermal tumors of the cervix
From: Ewing’s sarcoma of the cervix, a diagnostic dilemma: a case report and review of the literature
Author | Age | Symptoms | Diagnosis | Stage | Surgery | Chemotherapy/intent of chemotherapy | Radiation therapy | Outcome | |
|---|---|---|---|---|---|---|---|---|---|
1 | Russin et al. 1987 [21] | 60 | Vaginal bleeding | Path/IHC | IB | TAH + BSO + LND | VAC for 6 weeks/adjuvant | Yes | Alive at 16 months, NED |
2 | Sato et al. 1996 [22] | 44 | Irregular vaginal bleeding | Path/IHC | IB2 | TAH + BSO + LND, second look after 6 months | Cisplatin, VP16, cyclophosphamide (Cytoxan), doxorubicin (Adriamycin)/adjuvant | No | Alive 6 months, NED |
3 | Horn et al. 1997 [2] | 26 | Suspect cervical smear | Path/IHC | IB1 | TAH + BSO + LND | No adjuvant chemotherapy; had lung metastases 3 years after diagnosis, received 5FU and cisplatin/palliative | RT to metastases | Died 4.2 years after diagnosis |
4 | Cenacchi et al. 1998 [15] | 36 | Irregular vaginal bleeding | Path/IHC/RT-PCR | IB2 | TAH without BSO | No | No | Alive 18 months, NED |
5 | Pauwels et al. 2000 [14] | 45 | Irregular vaginal bleeding | Path/IHC/FISH | IB2 | TAH | No | Pelvic RT | Alive 42 months, NED |
6 | Tsao et al. 2001 [3] | 24 | Vaginal bleeding, urinary frequency | Path/IHC | TAH + transposition of ovaries + LNS | Two cycles, VAC alternating with IE, neoadjuvant and adjuvant | Yes | Alive 24 moths, NED | |
7 | Malpica and Moran 2002 [6] | 35 | Vaginal bleeding | Path/IHC | IB1 | TAH + BSO + LND | Adjuvant chemotherapy/regimen not reported | No | Alive 5 months, NED |
8 | Malpica and Moran 2002 [6] | 51 | Vaginal bleeding | Path/IHC | IB2 | TAH + BSO + LND | Adjuvant chemotherapy/regimen not reported | No | Alive 18 months, NED |
9 | Snijders-Keilholz and Ewing 2005 [17] | 21 | Intermenstrual bleeding | Path/IHC | IB2 | TAH without adnexectomy | Six courses of DIME/neoadjuvant; five courses of VIA/adjuvant | No | Alive 27 months, NED |
10 | Goda et al. 2007 [19] | 19 | Vaginal bleeding, discharge | No | Induction VAC, planned for further consolidation after RT | Yes | Alive, on treatment when reported | ||
11 | Farzaneh et al. 2011 [23] | 43 | Purulent vaginal discharge | Path/IHC | IB2 | TAH + BSO + LNS | 12 weeks of VAC alternating with IE/neoadjuvant | No | Alive 4 years, NED |
12 weeks of VAC alternating with IE/adjuvant | |||||||||
12 | Benbrahim et al. 2012 [9] | 25 | Irregular vaginal bleeding | Path/IHC | IIb | Coniztion with brachytherapy | Four cycles of Adriamycin and Cytoxan/neoadjuvant | Yes | Alive 8 years, NED |
13 | Arora et al. 2012 [4] | 23 | Irregular bleeding, dysuria | Path/IHC | TAH + BSO + LND | One cycle of CAV, followed by two cycles of cis/VP16/neoadjuvant | Yes | Alive 4 years, NED | |
14 | Masoura et al. 2012 [16] | 23 | Irregular bleeding, abdominal pain | Path/IHC/RT-PCR | IV | TAH + BSO | Cisplatin once/adjuvant | No. | Died, 12 days |
15 | Li et al. 2013 [5] | 27 | Contact bleeding, abdominal pain | Path/IHC | IIIB | Unresectable | VAC alternating with IE/definitive chemotherapy | Yes | Alive at 6 months, NED |
16 | Khosla et al. 2014 [24] | 28 | 10 weeks pregnant with vaginal bleeding and pelvic pain | Path/IHC | IB2 | Termination of pregnancy, TAH + BSO + LNS | Adriamycin, IE, for total of 6 weeks/adjuvant | No | Alive 33 months, NED |
17 | Xiao et al. 2014 [18] | 52 | Vaginal bleeding, uterine enlargement | Path/IHC | IIA | TAH + BSO + LND | Two courses of PVB | Pelvic recurrence 6 months, DOD 9 months | |
18 | Xiao et al. 2014 [18] | 59 | Cervix prolapse, vaginal bleeding | Path/IHC | IVB | TAH + BSO + LND | None | DOD | |
19 | Present case | 49 | Vaginal bleeding, lower abdominal pain | Path/IHC/FISH | IIB | TAH + BSO | Cisplatin/Etoposide with RT due to diagnosis of small cell VAC alternating with IE/adjuvant | Yes | Died, 10 months |