Thyroid metastasis from small cell lung carcinoma: a case report and review of the literature

Table 1 Clinical features of the current and previously reported* cases of small cell lung carcinoma with thyroid metastasis

Author, year, reference	Ozgu et al. 2012 [6]	Katsenos et al. 2013 [7]	Can and Köksal 2015 (this report)
Gender	Male	Male	Male
Age (years)	66	55	55
Comorbidities	CAD, CABG	CAD, PTCA, DM	HTN, HL, hip prosthesis
Smoking history	75 pack-year	40 pack-year	50 pack-year
Thyroid status	Hyperthyroid due to toxic MNG	Euthyroid†	Euthyroid
Other sites of metastasis‡	Adrenal mets	Cervical and mediastinal LN, cerebellar mets	Cerebral mets
Synchronicity	Synchronous	Synchronous	Metachronous
Time to detection of metastasis	NA	NA	6 months
Diagnosis of thyroid metastasis	FNA	FNA	FNA
Thyroidectomy	No	No	No
Treatment	Chemotherapy	Chemotherapy, cranial irradiation	Chemotherapy, lung and cranial irradiation
Survival after diagnosis of thyroid metastasis	11 months	18 months†	9 months

CABG coronary artery bypass grafting, CAD coronary artery disease, DM diabetes mellitus, FNA fine-needle aspiration biopsy of the thyroid, HL hyperlipidemia, HTN hypertension, LN lymph nodes, mets metastasis, MNG multinodular goiter, NA nonapplicable because of synchronous diagnosis of the small cell lung cancer and thyroid metastasis, PTCA percutaneous transluminal coronary angioplasty, *Literature review was based on clinical cases (not autopsies) and to articles published in the English language †personal e-mail communication with Stamatis Katsenos, MD, PhD on 16 November 2014, ‡represents other sites of metastasis when thyroid metastasis was diagnosed

ISSN: 1752-1947