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Table 1 Reported cases of McCune–Albright syndrome with Cushing’s syndrome, hepatobiliary and cardiovascular disease

From: Neonatal McCune–Albright syndrome with systemic involvement: a case report

Sex

Age

Cushing’s syndrome

Liver disease

Heart disease

Treatment/Outcome

Reference

F

37 days

+

Elevated LFTs

Cardiomegaly

Death (heart failure age 132 days)

[11]

M

10 months

+

Elevated LFTs, direct hyperbilirubinemia

Cardiomegaly, low ejection fraction, hypertension

Aminoglutethimide and metyrapone until age 2 years. Adrenalectomy at 2-years old. Death from cardiac arrest at age 3 years

[12]

F

2 months

+

Elevated LFTs, direct hyperbilirubinemia

Left ventricular hypertrophy

Adrenalectomy at 3 months. Death at age 2 years from anaphylaxis and/or adrenal insufficiency

[12]

M

10 weeks

+

Hepatomegaly

Cardiomegaly

NR

[13]

F

17 days

+

Elevated LFTs, direct hyperbilirubinemia, hepatomegaly

Left ventricular hypertrophy

Metyrapone. Death from pneumonia at age 4 months

Presented case

  1. F female, LFTs liver function tests, M male, NR not reported