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Table 1 Summary of results

From: Hepatitis B virus reactivation or reinfection in a FEM-PrEP participant: a case report

 

Date

ALT (IU/L)

AST (IU/L)

Hepatitis screen

Other tests (normal range)

Comment

Screening

13/08/2009

22

34

HBsAg = Negative

  

HBsAb = Positive HBsAb Value =11.19IU/L

RFU Wk 4a

21/09/2009

17

22

–

–

 

RFU Wk 12

16/11/2009

32

31

–

–

 

RFU Wk 24

09/02/2010

19

27

–

–

 

RFU Wk 36

07/05/2010

48

59

–

–

Grade 1a

RFU Wk 40

02/06/2010

117

95

–

–

Grade 2

RFU Wk 44

02/07/2010

1094

517

–

–

Grade 4

Unscheduled visit

09/07/2010

1,887

1,358

HBsAg = Positive

LDP = 1,298IU/L (200–500)

Diagnosis: Acute Hepatitis B

Permanent product withdrawal

  

HBeAg = Positive

GGT = 433IU/L (0–35)

HBc IgM = Positive

ALP = 68IU/L (40–120)

HBsAb = Positive

Total bilirubin = 38μmol/L (0–21)

HBsAb = 11.92IU/L

Direct bilirubin =20μmol/L (0–7)

HCV IgM = Negative

Epstein–Barr virus IgM = Negative

HAV IgM = Negative

Cytomegalovirus IgM = Negative

RFU Wk 48

26/07/2010

109

41

HBsAg = Positive

LDP = 485IU/L

Grade 2

HBeAg = Negative

HBc IgM = Positive

GGT = 178IU/L

HBsAb =11.39IU/L

ALP = 41IU/L

HBcAb = Positive

Total bilirubin = 15μmol/L

HBV VL = 87 cp/mL

Direct bilirubin =3.6μmol/L

International normalized ratio = 1.1

RFU Wk 52

23/08/2010

23

12

HBsAg = Negative

LDP = 484IU/L

Resolution of hepatitis B infection

HBV VL = 40 cp/mL

GGT = 49IU/L

HBsAb = 11.29IU/L

ALP = 36IU/L

RFU Wk 56

20/09/2010

22

12

–

–

 

Stored screening sample

12/09/2012

–

–

HBV-DNA PCR: Undetectable

–

Exclusion of occult Hepatitis B

  1. ALT alanine aminotransferase, ALP alkaline phosphatase, AST aspartate aminotransferase, GGT gamma-glutamyl transpeptide, HBV hepatitis B virus, HBcAb hepatitis B core antibodies, HBeAg hepatitis B e antigen, HBsAg hepatitis B surface antigen, HCV hepatitis VC virus, IgM immunoglobulin M, LDP lactate dehydrogenase phosphatase, PCR polymerase chain reaction; RFU Wk Regular follow-up week, VL viral load
  2. aAny abnormality in ALT/AST was graded according to the Division of AIDS grading scale [1]