Protein | Phenotypic consequencesa | Amino acid position/motifb | GZ 01502 | SH1 | AH1 | ZJLS01 | SZ040201H | SN040802G | CK/SZ097-1 | tree_sparrow/SH1 | pigeon/WX/0405007G |
---|---|---|---|---|---|---|---|---|---|---|---|
HA | Increased virus binding to human-type receptors (α2-6) | G186V | V | G | V | V | V | V | V | V | V |
Q226L | L | Q | L | L | L | Q | L | L | Q | ||
NA | Enhanced virulence in mice/adaption and transmission in domestic poultry | 69-73 amino acids deletion | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Related to drug resistance | R292K | R | K | R | K | R | R | R | R | R | |
PB2 | Increased virulence in mice | E627K | K | K | K | K | E | E | E | K | E |
Enhanced virulence and transmission in guinea pigs | D701N | D | D | D | D | D | D | D | D | D | |
PB1 | Increased transmission in ferret | I368V | V | I | V | V | V | V | V | V | V |
Increased replication in mammalian cells | L598P | L | M | L | L | L | L | L | L | L | |
PB1-F2 | Increased pathogenicity in mice | 87-90 amino acids in length | 90 | 90 | 90 | 90 | 90 | 90 | 25 | 90 | 90 |
PA | Increased polymerase activity | L336M | L | L | L | L | L | L | L | L | L |
Species-associated signature positions | V100A | A | A | A | A | A | A | A | A | A | |
K356R | R | R | R | R | R | R | R | R | R | ||
S409N | N | N | N | N | N | N | N | N | N |