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Table 3 Comparison of selected molecular markers between A/Guizhou/01502/2014 and representative H7N9 viruses

From: A returning migrant worker with avian influenza A (H7N9) virus infection in Guizhou, China: a case report

Protein Phenotypic consequencesa Amino acid position/motifb GZ 01502 SH1 AH1 ZJLS01 SZ040201H SN040802G CK/SZ097-1 tree_sparrow/SH1 pigeon/WX/0405007G
HA Increased virus binding to human-type receptors (α2-6) G186V V G V V V V V V V
Q226L L Q L L L Q L L Q
NA Enhanced virulence in mice/adaption and transmission in domestic poultry 69-73 amino acids deletion Yes Yes Yes Yes Yes Yes Yes Yes Yes
Related to drug resistance R292K R K R K R R R R R
PB2 Increased virulence in mice E627K K K K K E E E K E
Enhanced virulence and transmission in guinea pigs D701N D D D D D D D D D
PB1 Increased transmission in ferret I368V V I V V V V V V V
Increased replication in mammalian cells L598P L M L L L L L L L
PB1-F2 Increased pathogenicity in mice 87-90 amino acids in length 90 90 90 90 90 90 25 90 90
PA Increased polymerase activity L336M L L L L L L L L L
Species-associated signature positions V100A A A A A A A A A A
K356R R R R R R R R R R
S409N N N N N N N N N N
  1. aThe mutation to the right of the amino acid position confers the phenotype described below.
  2. bThe HA gene was under the H3 numbering system. The NA gene was under the N2 numbering system. Other internal genes were numbered from the start codon (Met).
  3. All letters in italics represent mutations detected at the relative position.