A returning migrant worker with avian influenza A (H7N9) virus infection in Guizhou, China: a case report

Table 3 Comparison of selected molecular markers between A/Guizhou/01502/2014 and representative H7N9 viruses

Protein	Phenotypic consequences^a	Amino acid position/motif^b	GZ 01502	SH1	AH1	ZJLS01	SZ040201H	SN040802G	CK/SZ097-1	tree_sparrow/SH1	pigeon/WX/0405007G
HA	Increased virus binding to human-type receptors (α2-6)	G186V	V	G	V	V	V	V	V	V	V
HA	Increased virus binding to human-type receptors (α2-6)	Q226L	L	Q	L	L	L	Q	L	L	Q
NA	Enhanced virulence in mice/adaption and transmission in domestic poultry	69-73 amino acids deletion	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
NA	Related to drug resistance	R292K	R	K	R	K	R	R	R	R	R
PB2	Increased virulence in mice	E627K	K	K	K	K	E	E	E	K	E
PB2	Enhanced virulence and transmission in guinea pigs	D701N	D	D	D	D	D	D	D	D	D
PB1	Increased transmission in ferret	I368V	V	I	V	V	V	V	V	V	V
PB1	Increased replication in mammalian cells	L598P	L	M	L	L	L	L	L	L	L
PB1-F2	Increased pathogenicity in mice	87-90 amino acids in length	90	90	90	90	90	90	25	90	90
PA	Increased polymerase activity	L336M	L	L	L	L	L	L	L	L	L
	Species-associated signature positions	V100A	A	A	A	A	A	A	A	A	A
		K356R	R	R	R	R	R	R	R	R	R
		S409N	N	N	N	N	N	N	N	N	N

^aThe mutation to the right of the amino acid position confers the phenotype described below.
^bThe HA gene was under the H3 numbering system. The NA gene was under the N2 numbering system. Other internal genes were numbered from the start codon (Met).
All letters in italics represent mutations detected at the relative position.