HA
|
Increased virus binding to human-type receptors (α2-6)
|
G186V
|
V
|
G
|
V
|
V
|
V
|
V
|
V
|
V
|
V
|
Q226L
|
L
|
Q
|
L
|
L
|
L
|
Q
|
L
|
L
|
Q
|
NA
|
Enhanced virulence in mice/adaption and transmission in domestic poultry
|
69-73 amino acids deletion
|
Yes
|
Yes
|
Yes
|
Yes
|
Yes
|
Yes
|
Yes
|
Yes
|
Yes
|
Related to drug resistance
|
R292K
|
R
|
K
|
R
|
K
|
R
|
R
|
R
|
R
|
R
|
PB2
|
Increased virulence in mice
|
E627K
|
K
|
K
|
K
|
K
|
E
|
E
|
E
|
K
|
E
|
Enhanced virulence and transmission in guinea pigs
|
D701N
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
PB1
|
Increased transmission in ferret
|
I368V
|
V
|
I
|
V
|
V
|
V
|
V
|
V
|
V
|
V
|
Increased replication in mammalian cells
|
L598P
|
L
|
M
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
PB1-F2
|
Increased pathogenicity in mice
|
87-90 amino acids in length
|
90
|
90
|
90
|
90
|
90
|
90
|
25
|
90
|
90
|
PA
|
Increased polymerase activity
|
L336M
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
Species-associated signature positions
|
V100A
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
K356R
|
R
|
R
|
R
|
R
|
R
|
R
|
R
|
R
|
R
|
S409N
|
N
|
N
|
N
|
N
|
N
|
N
|
N
|
N
|
N
|