Drugs’ interaction timeline and pharmacokinetics. The figure reports the four drugs administered to the patient at the same time (ethinyl estradiol/drospirenone, clozapine, fluconazole, miconazole) and the onset and duration of the adverse drug reactions. The peak of clozapine plasma level (542ng/mL) was observed after 18 days. Adverse drug reactions were observed 2 days after clozapine peak and lasted 14 days. Abbreviation: ADRs, adverse drug reactions.