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Table 2 Response to earlier medications and other treatments in 32 patients presenting to Mayo Clinic with erythromelalgia[8]

From: An Egyptian child with erythromelalgia responding to a new line of treatment: a case report and review of the literature

Drugs used No. of patients, response
  n Very helpful Somewhat helpful Not helpful
Aspirin 14 1 2 11
NSAIDs (ibuprofen, indomethacin, naproxen) 14 1 0 13
Antidepressants (amitriptyline hydrochloride, venlafaxine, cyproheptadine hydrochloride) 10 2 2 6
Antihistamines (diphenhydramine, cetirizine hydrochloride, cimetidine) 8 0 0 8
Vasodilators (nitroprusside, nifedipine, diltiazem) 7 1 1 5
Β-blockers (propranolol, atenolol, nadolol) 6 0 1 5
Narcotics (codeine, morphine, fentanyl) 6 0 4 2
Gabapentin 6 2 0 4
Parenteral corticosteroids (oral, intramuscular, intravenous) 6 0 1 5
Topical corticosteroids 5 0 0 5
Physical methods (biofeedback, intrathecal pump, TENS unit) 4 1 1 2
Other anticonvulsants (carbamazepine, phenytoin) 3 0 1 2
Sympathectomy 3 0 1 2
Acetaminophen 3 0 1 2
Other medications* (doxazosin mesylate, capsaicin, ergotamine tartrate, mexiletine, clonidine, tetracycline, homeopathic) 7 0 0 7
  1. NSAIDs, nonsteroidal anti-inflammatory drugs; TENS, transcutaneous electrical nerve stimulation.
  2. *Each drug given to one patient and all of them gave a “not helpful” response.