Table 2 Response to earlier medications and other treatments in 32 patients presenting to Mayo Clinic with erythromelalgia[8]
Drugs used | No. of patients, response | |||
|---|---|---|---|---|
n | Very helpful | Somewhat helpful | Not helpful | |
Aspirin | 14 | 1 | 2 | 11 |
NSAIDs (ibuprofen, indomethacin, naproxen) | 14 | 1 | 0 | 13 |
Antidepressants (amitriptyline hydrochloride, venlafaxine, cyproheptadine hydrochloride) | 10 | 2 | 2 | 6 |
Antihistamines (diphenhydramine, cetirizine hydrochloride, cimetidine) | 8 | 0 | 0 | 8 |
Vasodilators (nitroprusside, nifedipine, diltiazem) | 7 | 1 | 1 | 5 |
Β-blockers (propranolol, atenolol, nadolol) | 6 | 0 | 1 | 5 |
Narcotics (codeine, morphine, fentanyl) | 6 | 0 | 4 | 2 |
Gabapentin | 6 | 2 | 0 | 4 |
Parenteral corticosteroids (oral, intramuscular, intravenous) | 6 | 0 | 1 | 5 |
Topical corticosteroids | 5 | 0 | 0 | 5 |
Physical methods (biofeedback, intrathecal pump, TENS unit) | 4 | 1 | 1 | 2 |
Other anticonvulsants (carbamazepine, phenytoin) | 3 | 0 | 1 | 2 |
Sympathectomy | 3 | 0 | 1 | 2 |
Acetaminophen | 3 | 0 | 1 | 2 |
Other medications* (doxazosin mesylate, capsaicin, ergotamine tartrate, mexiletine, clonidine, tetracycline, homeopathic) | 7 | 0 | 0 | 7 |