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Table 1 Review of the most relevant literature on treatment of cheilitis granulomatosa

From: Buccal localization of Crohn’s disease with long-term infliximab therapy: a case report

Author, year of publication Diagnosis Number of cases Therapy Results
Martinez Martinez et al . 2012 [14] CG 6 TCA sulfone, oral steroids, tetracyclines, hydroxychloroquine, amoxicillin-clavulanic acid Moderate (1 recurrence)
Ruiz Villaverde and Sanchez, 2012 [15] CG 1 Adalimumab Good
Álvarez-Garrido et al ., 2011 [16] CD + CG 1 Remicade Good
Macaigne et al ., 2011 [17] CD + CG 1 Remicade Good
Sasaki et al ., 2011 [18] CG 1 Dental treatment Markedly improved
Kawakami et al ., 2008 [19] CG 1 Corticosteroid ointment and oral tranilast None
Paradentitis treatment Good
Mignogna et al ., 2008 [9] CD 1 TCA Good
Inui, 2008 [20] CG 1 Roxithromycin Good
Ratzinger et al ., 2007 [21] CG 1 Methylprednisolone, Clofazimine Moderate
UG + CD 1 None None
MRS 1 Clofazimine Good
CG 1 Clofazimine Good
CG 1 Clofazimine None
CG 1 Clofazimine Good
MRS 1 Clofazimine Good
BG 1 Clofazimine Good
PG 1 Clofazimine Good
CG + CD 1 Methylprednisolone, Azathioprine Good
MRS 1 Methylprednisolone, Infliximab Good
CG 1 None None
CG + CD 1 Methylprednisolone, Azathioprine, Infliximab Good
PG + CD 1 Clofazimine Good
Tonkovic-Capin, 2006 [22] CD +CG 1 Methotrexate Good
Kruse-Losler et al ., 2005 [23] MRS 3 Cheiloplasty Good
CG 4
Bogenrieder et al ., 2003 [24] CG + CD 1 Mesalazine, Good
prednisolone per os
Hegarty et al ., 2003 [25] CD + CG 5 Thalidomide Good
Sciubba et al ., 2003 [26] MRS + oral granulomatosis 7 TCA chlorhexidine, Moderate
  CD + CG 6 TCA, systemic sulfasalazine/steroids Moderate
Kolokotronis et al ., 1997 [27] CG 5 In 3 intralesional corticosteroids Good
    In 2 oral corticosteroids [2]  
Ochonisky et al ., 1992 [28] CD 1 Hydroxychloroquine Good
Krutchkoff and James, 1978 [29] CG 1 TCA +cheiloplasty Good
  1. CG, cheilitis granulomatosa; CD, Crohn’s disease; TCA, triamcinolone acetate intralesional injections; UG, uranitis granulomatosa; PG, pareitis granulomatosa; BG, blepharitis granulomatosa.
  2. Results: none =no remission, moderate =partial remission, good =complete remission. MRS: Melkersson–Rosenthal syndrome.