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Table 1 Clinical features of nine patients with solid organ cancer and pulmonary alveolar proteinosis reported in the literature

From: Autoimmune pulmonary alveolar proteinosis co-existing with breast cancer: a case report

Case/Ref

Sex/age (y)

Presentation

Clinical form

GM-CSF Ab

Cancer

Timing of cancer and PAP

1/2)

M/24

Weight loss

Unknown

N.A.

Melanoma

Co-incident

2/3)

M/64

Lt. hemiplegia

Unknown

N.A.

Glioblastoma

Cancer first

3/4)

M/67

Cough, Sputum

Unknown

N.A.

Lung cancer (SCC)

Co-incident

4/5)

M/59

Cough, Dyspnea

Unknown

N.A.

Lung cancer (SCC)

Co-incident

5/6)

M/45

Chest pain

Unknown

N.A.

Mesothelioma

PAP first

6/7)

F/54

Dyspnea

Autoimmune

Positive

Lung cancer (Adeno)

PAP first

7/7)

F/59

Dyspnea

Unknown

N.A.

Lung cancer (Adeno)

Co-incident

8/8)

M/57

Cough, Sputum

Secondary

Negative

Lung cancer (SCC)

PAP first

9/our case

F/48

Asymptomatic

Autoimmune

Positive

Breast cancer

Co-incident

  1. GM-CSF Ab, granulocyte-macrophage colony-stimulating factor antibody; PAP, pulmonary alveolar proteinosis; N.A., not available; SCC, squamous cell carcinoma; Adeno, adenocarcinoma.