From: Clear cell urothelial carcinoma of the urinary bladder: a case report and review of the literature
Antibody specificity | Tumor cell reactivity | Source | Clone | Positive controls |
---|---|---|---|---|
Cytokeratin 7 | Approx. 75%, cell membrane and cytoplasm | Dako | OV-TL12/30 | Breast carcinoma |
p53 | Approx. 30%, nuclear | Dako | DO-7 | Breast cancer |
p63 | >80%, nuclear | Biocare | 4A4 | Breast myoepithelial cells |
Vimentin | Approx. 80%, cell membrane and cytoplasm | Ventana | 3B4 | Salivary gland |
Ki-67 | >70%, nuclear | Ventana | 30-9 | Tonsil |
CD10 | Approx. 15%, cell membrane | Cell Marque | 56C6 | Tonsil |
E-cadherin | Approx. 10%, cell membrane | Cell Marque | ECH-6 | Breast ductal carcinoma |
CA125 | Negative | Cell Marque | OC1-25 | Ovarian carcinoma |
CAM 5.2 | Negative | Becton Dickinson | CAM 5.2 | Cholangiocarcinoma |
CD117 | Negative | Dako | c-kit | Gastrointestinal stromal |
Cytokeratin 20 | Negative | Biocare | Ks 20.8 | Large intestinal epithelium |
MAA | Negative | Ventana | HMB-45 | Melanoma |
PAX 8 | Negative | Cell Marque | MRQ-50 | Nonmucinous ovarian |
PLAP | Negative | Ventana | NB10 | Placenta |
PSA | Negative | Ventana | Rabbit polyc. | Prostate |
RCC | Negative | Cell Marque | PN-15 | Renal cell tubular epithelium |
S-100 protein | Negative | Ventana | 4C4.9 | Melanoma |
Uroplakin III | Negative | Cell Marque | SP73 | Urothelial carcinoma |
Special histochemical stain | Reactivity | Â | Â | Â |
PAS | Positive cytoplasm | Ventana | Â | Cirrhotic liver |
PAS-diastase | Negative | Ventana | Â | Cirrhotic liver |
Mucicarmine | Negative | Manual | Â | Small intestinal epithelium |
Oil red O (frozen section) | Negative | Manual | Â | Perivesical adipose tissue |