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Table 1 Special immunoperoxidase and histochemical stains

From: Clear cell urothelial carcinoma of the urinary bladder: a case report and review of the literature

Antibody specificity

Tumor cell reactivity

Source

Clone

Positive controls

Cytokeratin 7

Approx. 75%, cell membrane and cytoplasm

Dako

OV-TL12/30

Breast carcinoma

p53

Approx. 30%, nuclear

Dako

DO-7

Breast cancer

p63

>80%, nuclear

Biocare

4A4

Breast myoepithelial cells

Vimentin

Approx. 80%, cell membrane and cytoplasm

Ventana

3B4

Salivary gland

Ki-67

>70%, nuclear

Ventana

30-9

Tonsil

CD10

Approx. 15%, cell membrane

Cell Marque

56C6

Tonsil

E-cadherin

Approx. 10%, cell membrane

Cell Marque

ECH-6

Breast ductal carcinoma

CA125

Negative

Cell Marque

OC1-25

Ovarian carcinoma

CAM 5.2

Negative

Becton Dickinson

CAM 5.2

Cholangiocarcinoma

CD117

Negative

Dako

c-kit

Gastrointestinal stromal

Cytokeratin 20

Negative

Biocare

Ks 20.8

Large intestinal epithelium

MAA

Negative

Ventana

HMB-45

Melanoma

PAX 8

Negative

Cell Marque

MRQ-50

Nonmucinous ovarian

PLAP

Negative

Ventana

NB10

Placenta

PSA

Negative

Ventana

Rabbit polyc.

Prostate

RCC

Negative

Cell Marque

PN-15

Renal cell tubular epithelium

S-100 protein

Negative

Ventana

4C4.9

Melanoma

Uroplakin III

Negative

Cell Marque

SP73

Urothelial carcinoma

Special histochemical stain

Reactivity

   

PAS

Positive cytoplasm

Ventana

 

Cirrhotic liver

PAS-diastase

Negative

Ventana

 

Cirrhotic liver

Mucicarmine

Negative

Manual

 

Small intestinal epithelium

Oil red O (frozen section)

Negative

Manual

 

Perivesical adipose tissue

  1. CA, Cancer antigen; CAM, Cell adhesion molecule; CD, Cluster of differentiation; MAA, melanoma-associated antigen; PAS, periodic acid-Schiff; PAX, Paired box protein; PLAP, Placental alkaline phosphatase; PSA, Prostate-specific antigen; RCC, Renal cell carcinoma.