Figure 2
From: Clear cell urothelial carcinoma of the urinary bladder: a case report and review of the literature
Hematoxylin and eosin staining of the cystectomy specimen. (A) Sheets of clear cells can be seen invading through the muscularis propria into the perivesical adipose tissue (10× objective). (B) Rounded to polygonal malignant cells with severe nuclear atypia, prominent nucleoli, and abundant, clear cytoplasm seen under a 40× objective. (C) These cells were positive for periodic acid-Schiff, which (D) disappeared with diastase treatment. (E-H) Immunoperoxidase stains show tumor cells with strong positive membrane staining for CK7 (E), approximately 30% nuclear staining for p53 antigen (F), >80% nuclear staining for p63 antigen (G), and >70% nuclear staining for Ki-67 (MIB-1) antigen (H). Figures B through H at 40× objective.