Uncommon serum creatine phosphokinase and lactic dehydrogenase increase during diosmin therapy: two case reports

Table 1 Patients’ characteristics

Pt	Sex	Weight (Kg)	Age (years)	Drug	Posology	AEs	Dechallenge	Rechallenge	Concomitant therapy
1	F	70	55	diosmin 450mg	1 bid	increased CPK, myalgia	yes*	yes	amiloride, hydrochlorothiazide
2	F	85	70	diosmin 450mg + hesperidin 50mg	1 tid	hives	yes
3	F	65	80	diosmin 450mg + hesperidin 50mg	1 tid	hives	yes
4	F	60	41	diosmin 450mg + hesperidin 50mg	1 tid	hives	yes
5	F	65	81	diosmin 450mg + hesperidin 50mg	1 tid	diffused itching	yes		parnaparin, prednisone, citalopram, rabeprazole, acetylsalicylic acid, simvastatin, amlodipine
6	F	55	23	diosmin 450mg + hesperidin 50mg	1 tid	tachycardia	no*		local medication (for perianal fistulectomy)
7	F	75	36	diosmin 450mg	1 bid	epigastric pain, fainting	yes		lisinopril, acetylsalicylic acid
8	F	95	65	diosmin 450mg	1 bid	epigastric pain	yes	yes	amlodipine, telmisartan
9	F	68	71	diosmin 450mg	1 bid	epigastric pain	yes
10	F	70	53	diosmin 450mg + hesperidin 50mg	1 tid	epigastric pain	yes
11	M	70	43	diosmin 450mg + hesperidin 50mg	1 tid	diarrhea	yes
12	M	65	43	diosmin 450mg	1 bid	diarrhea	no
13	F	73	35	diosmin 450mg	1 bid	itching	yes
14	F	80	69	diosmin 450mg	1 bid	epigastric pain	no
15	F	77	66	diosmin 450mg	1 bid	asthenia, nausea	no
16	M	80	79	diosmin 450mg	2 tid	increased LDH	yes		anal topical application, amlodipine
17	F	75	53	diosmin 450mg + hesperidin 50mg	1 tid	hives	yes		cefixime, rabeprazole, acetylsalicylic acid, carvedilol, amlodipine, levothyroxine, simvastatin

AEs, adverse events; bid, twice a day; CPK, creatine phosphokinase; F, female; LDH, lactic dehydrogenase; M, male; Pt, patient; tid, three times a day; *yes, means that the side effects resolved after the drug was stopped; *no, means that the event resolved before the drug was stopped.

ISSN: 1752-1947