Substantially increased sildenafil bioavailability after sublingual administration in children with congenital heart disease: two case reports

Table 1 Pharmacokinetic parameters of sildenafil and N -desmethyl sildenafil ^a

Case	Sildenafil AUC_0–6h((ng/ml)×h)			N-desmethyl sildenafil AUC_0–6h((ng/ml)×h)			MR			Absolute bioavailability (%)
	IV	Ent	SL	IV	Ent	SL	IV	Ent	SL	IV	Ent	SL
1	–	5.76	26.6	–	31.8	42.8	–	0.18	0.6	–	–	–
2	919	25.5	106	70.4	74.7	37.2	12.7	0.33	2.78	100	2.78	11.6

^aAUC_0–6h, Estimated area under the concentration–time curve in a 6-hour dosing interval, normalized to dose; IV, Intravenous; Enteral; SL, Sublingual; MR, Metabolic sildenafil/N-desmethyl sildenafil ratio.

ISSN: 1752-1947