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Table 1 Pharmacokinetic parameters of sildenafil and N -desmethyl sildenafil a

From: Substantially increased sildenafil bioavailability after sublingual administration in children with congenital heart disease: two case reports

Case Sildenafil AUC0–6h((ng/ml)×h) N-desmethyl sildenafil AUC0–6h((ng/ml)×h) MR Absolute bioavailability (%)
  IV Ent SL IV Ent SL IV Ent SL IV Ent SL
1 5.76 26.6 31.8 42.8 0.18 0.6
2 919 25.5 106 70.4 74.7 37.2 12.7 0.33 2.78 100 2.78 11.6
  1. aAUC0–6h, Estimated area under the concentration–time curve in a 6-hour dosing interval, normalized to dose; IV, Intravenous; Enteral; SL, Sublingual; MR, Metabolic sildenafil/N-desmethyl sildenafil ratio.