Table 1 The diagnostic criteria of hypomelanosis of Ito

1 (sine qua non)

Congenital or early acquired nonhereditary cutaneous hypopigmentation in linear streaks or patches involving more than two body segments.

2 (major)

One or more central nervous system anomalies; one or more musculoskeletal anomalies.

3 (minor)

Two or more congenital malformations other than central nervous system or musculoskeletal. Chromosomal anomalies.

Definitive diagnosis

Criterion 1 plus one or more criterion 2 or two or more criterion 3.

Presumptive diagnosis

Criterion 1 alone or in association with one minor criterion.