Linezolid-induced black hairy tongue: a case report

Table 1 Reported cases of linezolid-induced tongue discoloration and black hairy tongue

Patient gender, age (years)	Clinical indication for linezolid therapy	Concomitantly used medications	Naranjo score	Ref #
Male, 65*	Ampicillin-resistant enterococcal UTI in a kidney transplant recipient	Mycophenolate, tacrolimus, prednisone, TMP and SMX, nystatin, valgancyclovir	7	[5]
Male, 74	Staphylococcal skin infection in a lymphoma patient	NR	6	[7]
Female, 8**	MRSA septic arthritis	NR	6	[8]
Male, 42*	Empiric therapy for diskitis following laminectomy	Rifampin	6	[6]
Female, 40	Disseminated nocardial infection in a patient with SLE	Steroids, azathioprine, ceftriaxone, TMP and SMX	6	[9]
Male, 56	Empirical therapy for MRSA pneumonia	Ertapenem, hydrocodone and acetaminophen, albuterol and ipratropium bromide MDI	6	Current case

Abbreviations: MDI: metered-dose inhaler, MRSA: methicillin-resistant Staphylococcus aureus, NR: not reported, Ref #: reference number, SLE: systemic lupus erythematosus, TMP and SMX: trimethoprim and sulfamethoxazole, UTI: urinary tract infection.
*The authors did not observe filiform papillae changes on clinical examination and labeled their patients with linezolid-induced tongue discoloration not black hairy tongue.
**The authors described tongue discoloration but did not comment on the possibility of black hairy tongue.

ISSN: 1752-1947