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Table 1 Reported cases of linezolid-induced tongue discoloration and black hairy tongue

From: Linezolid-induced black hairy tongue: a case report

Patient gender, age (years) Clinical indication for linezolid therapy Concomitantly used medications Naranjo score Ref #
Male, 65* Ampicillin-resistant enterococcal UTI in a kidney transplant recipient Mycophenolate, tacrolimus, prednisone, TMP and SMX, nystatin, valgancyclovir 7 [5]
Male, 74 Staphylococcal skin infection in a lymphoma patient NR 6 [7]
Female, 8** MRSA septic arthritis NR 6 [8]
Male, 42* Empiric therapy for diskitis following laminectomy Rifampin 6 [6]
Female, 40 Disseminated nocardial infection in a patient with SLE Steroids, azathioprine, ceftriaxone, TMP and SMX 6 [9]
Male, 56 Empirical therapy for MRSA pneumonia Ertapenem, hydrocodone and acetaminophen, albuterol and ipratropium bromide MDI 6 Current case
  1. Abbreviations: MDI: metered-dose inhaler, MRSA: methicillin-resistant Staphylococcus aureus, NR: not reported, Ref #: reference number, SLE: systemic lupus erythematosus, TMP and SMX: trimethoprim and sulfamethoxazole, UTI: urinary tract infection.
  2. *The authors did not observe filiform papillae changes on clinical examination and labeled their patients with linezolid-induced tongue discoloration not black hairy tongue.
  3. **The authors described tongue discoloration but did not comment on the possibility of black hairy tongue.