TY - JOUR AU - Simon, Ole Jan AU - Kuhlmann, Tanja AU - Bittner, Stefan AU - Müller-Tidow, Carsten AU - Weigt, Jochen AU - Wiendl, Heinz AU - Meuth, Sven G. PY - 2013 DA - 2013/12/03 TI - Evans syndrome associated with sterile inflammation of the central nervous system: a case report JO - Journal of Medical Case Reports SP - 262 VL - 7 IS - 1 AB - Evans syndrome is a rare hematological disease commonly defined as Coombs-positive hemolytic anemia and immune thrombocytopenia. Pathophysiology of this disease involves decreased cluster of differentiation (CD)4+ T-helper cell counts, increased CD8+ T-suppressor cell counts, a decreased CD4/CD8 ratio, and reduced serum immunoglobulin G, M and A levels - indicating a complex immune dysregulation. Association with other autoimmune diseases has been described although involvement of the central nervous system has not been reported so far. SN - 1752-1947 UR - https://doi.org/10.1186/1752-1947-7-262 DO - 10.1186/1752-1947-7-262 ID - Simon2013 ER -