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Table 1 Current and prior case reports of co-inherited cystic fibrosis and sickle cell disease

From: A 2-year-old girl with co-inherited cystic fibrosis and sickle cell-β+ thalassemia presenting with recurrent vaso-occlusive events during cystic fibrosis pulmonary exacerbations: a case report

Reference Cystic fibrosis genotype Cystic fibrosis complications Hemoglobin disease classification Hematologic complications Co-morbid conditions
Porter et al. [9] Unknown -Meconium ileus Hemoglobin SS -Acute transfusions -None reported
Porter et al. [9] Unknown -Recurrent bronchitis Hemoglobin SS -Anemia -None reported
Amendola et al. [10] Unknown -Recurrent bronchitis Hemoglobin SD -Chronic transfusions -None reported
-Pancreatic insufficiency
Warwick et al. [11] Unknown -Recurrent bronchitis Hemoglobin SS -Bone pain -Cardiomegaly
-Pancreatic insufficiency
Banjar [12] H549L/S549R -Sinusitis Hemoglobin SS -Bone pain -Obstructive sleep apnea
-Recurrent bronchitis   -Chronic transfusions -Hypercalciuria
-Pancreatic insufficiency    -Gastroesophageal reflux
Current case C53+2T>C/Unknown -Recurrent bronchitis Hemoglobin-β+ thalassemia -Bone pain -Gastroesophageal reflux
-Failure to thrive   -Abdominal sequestration -Nissen fundoplication
-Burkholderia cepacia   -Acute chest syndrome -Gastrostomy tube
-Pancreatic insufficiency   -Chronic transfusions -Central line infections
    -Lactase deficiency
-Total parenteral nutrition