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Table 1 Summarized data of all reported NF1 cases with lymphoma development

From: Diffuse large B cell lymphoma presenting as Horner's syndrome in a patient diagnosed with neurofibromatosis type 1: a case report and review of the literature

Case
No.
References Sex/
Age at onset (y)
Lymphoma Other tumor(s) Presentation of lymphoma Family history of
NF1
Family history of
cancer
NF criteria* Treatment Outcome
1. [16] F, 20 Burkitt lymphoma Pheochromocytoma dental extract site mass NA NA CALM, neurofibromas Chemotherapy and radiotherapy Alive
2. [17] M, 11 Diffuse, poorly differentiated
lymphoma
Glioblastoma multiforme anterior mediastinal mass Y Y CALM Chemotherapy Death
3. [18] F, 6 T-cell lymphoblastic lymphoma Gardner syndrome mediastinal mass and pleural effusion Y Y CALM Chemotherapy and radiotherapy Death
4. [18] F, 1.1 T-cell lymphoblastic lymphoma   neck mass Y Y CALM Radiotherapy Death
5. [18] M, 4 T-cell lymphoblastic lymphoma   mediastinal mass and pleural effusion Y Y CALM, neurofibromas Chemotherapy and radiotherapy Death
6. [7] M, 16 T-cell lymphoma Acute lymphoblastic leukemia,15 months after diagnosis of lymphoma mediastinal mass Y Y CALM Chemotherapy and radiotherapy Death
7. [19] M, 45 Well-differentiated lymphocytic lymphoma Pheochromocytoma, renal artery stenosis abdominal mass NA NA CALM, neurofibromas NA Alive
8. [20] M, 59 Diffuse, medium sized cell type, B cell type NHL   lymphadenopathy Y NA CALM, neurofibromas Chemotherapy Death
9. [21] M, 7.8 T-NHL Acute lymphoblastic leukemia, prior to NHL   Y Y NA NA Death
10. [21] F, 4.1 T-NHL    Y Y NA NA Death
11. [21] M, 1.6 T-NHL    Y Y NA NA Death
12. [21] M, 13.7 Mixed
centroblastic/
centrocytic NHL
   Y NA NA NA Alive
13. [21] M, 7.2 B- NHL    N NA NA NA Death
14. [22] F, 4.6 B-cell NHL Glioblastoma multiforme right iliac fossa mass N N CALM, neurofibromas Chemotherapy Alive
15. [23] M, 65 Diffuse mixed type, T cell type NHL   generalized lymphadenopathy Y NA CALM, neurofibromas Chemotherapy Death
16. [24] F, 2** Undifferentiated NHL    Y Y CALM, neurofibromas, pseudoarthrosis NA Death
17. [25] M, 3.3** NHL    Y Y CALM NA Death
18. [26] M, 44 Cutaneous T-cell lymphoma Astrocytoma skin rash NA NA CALM, neurofibromas, freckles Phototherapy and topical steroid Alive
19. [27] F, 77 DLBCL   left lower abdominal mass and weight loss Y NA CALM, neurofibromas Chemotherapy Alive
20. [28] M, 2 T-cell NHL Colorectal cancer testicular and mediastinal mass Y NA CALM, freckle Chemotherapy and radiotherapy Alive
21. [29] M, 72 Cutaneous T-cell lymphoma   skin rash Y NA CALM, neurofibromas, freckles, Lisch nodules NA Alive
22. [30] M, 47 CNS lymphoma, B cell type   parieto-occipital lobe mass NA NA Neurofibromas, Lisch nodules NA NA
23. [31] M, 9.4 T-cell lymphoma Anaplastic astrocytoma mediastinal mass N Y CALM, freckles Chemotherapy Death
24. [32] M, 5*** Lymphoblastic lymphoma Colorectal cancer   Y Y CALM, freckles NA Death
25. [33] F,50 DLBCL   shoulder mass N N CALM, neurofibromas Chemotherapy Alive
26. [34] F, 6 Mediastinal T-cell lymphoblastic lymphoma Gaucher's disease   NA NA NA NA NA
27. Present case M, 28 DLBCL   neck mass N N CALM, neurofibromas,
freckles, Lisch nodules
Chemotherapy Alive
  1. Abbreviations: CALM, café au lait macules; CNS, central nervous system; DLBCL, diffuse large B-cell lymphoma; F, female; M, male; N, No; NA, not available; NF, neurofibromatosis; NF1, neurofibromatosis type 1; NHL, non-Hodgkin's lymphoma; y, years; Y, Yes;
  2. *Freckles include axillary or inguinal freckles
  3. ** Presence of MLH1 (human mutL homolog 1) mutation
  4. ***Presence of MSH6 (human mutS homolog 6) mutation