Table 1 Summarized data of all reported NF1 cases with lymphoma development
Case No. | References | Sex/ Age at onset (y) | Lymphoma | Other tumor(s) | Presentation of lymphoma | Family history of NF1 | Family history of cancer | NF criteria* | Treatment | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
1. | [16] | F, 20 | Burkitt lymphoma | Pheochromocytoma | dental extract site mass | NA | NA | CALM, neurofibromas | Chemotherapy and radiotherapy | Alive |
2. | [17] | M, 11 | Diffuse, poorly differentiated lymphoma | Glioblastoma multiforme | anterior mediastinal mass | Y | Y | CALM | Chemotherapy | Death |
3. | [18] | F, 6 | T-cell lymphoblastic lymphoma | Gardner syndrome | mediastinal mass and pleural effusion | Y | Y | CALM | Chemotherapy and radiotherapy | Death |
4. | [18] | F, 1.1 | T-cell lymphoblastic lymphoma | Â | neck mass | Y | Y | CALM | Radiotherapy | Death |
5. | [18] | M, 4 | T-cell lymphoblastic lymphoma | Â | mediastinal mass and pleural effusion | Y | Y | CALM, neurofibromas | Chemotherapy and radiotherapy | Death |
6. | [7] | M, 16 | T-cell lymphoma | Acute lymphoblastic leukemia,15 months after diagnosis of lymphoma | mediastinal mass | Y | Y | CALM | Chemotherapy and radiotherapy | Death |
7. | [19] | M, 45 | Well-differentiated lymphocytic lymphoma | Pheochromocytoma, renal artery stenosis | abdominal mass | NA | NA | CALM, neurofibromas | NA | Alive |
8. | [20] | M, 59 | Diffuse, medium sized cell type, B cell type NHL | Â | lymphadenopathy | Y | NA | CALM, neurofibromas | Chemotherapy | Death |
9. | [21] | M, 7.8 | T-NHL | Acute lymphoblastic leukemia, prior to NHL | Â | Y | Y | NA | NA | Death |
10. | [21] | F, 4.1 | T-NHL | Â | Â | Y | Y | NA | NA | Death |
11. | [21] | M, 1.6 | T-NHL | Â | Â | Y | Y | NA | NA | Death |
12. | [21] | M, 13.7 | Mixed centroblastic/ centrocytic NHL | Â | Â | Y | NA | NA | NA | Alive |
13. | [21] | M, 7.2 | B- NHL | Â | Â | N | NA | NA | NA | Death |
14. | [22] | F, 4.6 | B-cell NHL | Glioblastoma multiforme | right iliac fossa mass | N | N | CALM, neurofibromas | Chemotherapy | Alive |
15. | [23] | M, 65 | Diffuse mixed type, T cell type NHL | Â | generalized lymphadenopathy | Y | NA | CALM, neurofibromas | Chemotherapy | Death |
16. | [24] | F, 2** | Undifferentiated NHL | Â | Â | Y | Y | CALM, neurofibromas, pseudoarthrosis | NA | Death |
17. | [25] | M, 3.3** | NHL | Â | Â | Y | Y | CALM | NA | Death |
18. | [26] | M, 44 | Cutaneous T-cell lymphoma | Astrocytoma | skin rash | NA | NA | CALM, neurofibromas, freckles | Phototherapy and topical steroid | Alive |
19. | [27] | F, 77 | DLBCL | Â | left lower abdominal mass and weight loss | Y | NA | CALM, neurofibromas | Chemotherapy | Alive |
20. | [28] | M, 2 | T-cell NHL | Colorectal cancer | testicular and mediastinal mass | Y | NA | CALM, freckle | Chemotherapy and radiotherapy | Alive |
21. | [29] | M, 72 | Cutaneous T-cell lymphoma | Â | skin rash | Y | NA | CALM, neurofibromas, freckles, Lisch nodules | NA | Alive |
22. | [30] | M, 47 | CNS lymphoma, B cell type | Â | parieto-occipital lobe mass | NA | NA | Neurofibromas, Lisch nodules | NA | NA |
23. | [31] | M, 9.4 | T-cell lymphoma | Anaplastic astrocytoma | mediastinal mass | N | Y | CALM, freckles | Chemotherapy | Death |
24. | [32] | M, 5*** | Lymphoblastic lymphoma | Colorectal cancer | Â | Y | Y | CALM, freckles | NA | Death |
25. | [33] | F,50 | DLBCL | Â | shoulder mass | N | N | CALM, neurofibromas | Chemotherapy | Alive |
26. | [34] | F, 6 | Mediastinal T-cell lymphoblastic lymphoma | Gaucher's disease | Â | NA | NA | NA | NA | NA |
27. | Present case | M, 28 | DLBCL | Â | neck mass | N | N | CALM, neurofibromas, freckles, Lisch nodules | Chemotherapy | Alive |