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Figure 4 | Journal of Medical Case Reports

Figure 4

From: 18F-fluoro-deoxyglucose positron emission tomography/computed tomography scan findings in Rosai-Dorfman disease with IgG4-positive plasma cell infiltration mimicking breast malignancy: a case report and literature review

Figure 4

Histopathological images and immunohistochemical staining of the mammary lesion. (A) High-power photomicrograph shows distinctive histiocytes of Rosai-Dorfman disease that are large with abundant and finely granular pink cytoplasm and relatively large nuclei with open chromatin and distinct nucleoli. Engulfment of intact lymphocytes and plasma cells by the large histiocytes, a phenomenon known as emperipolesis (arrow), is shown (stain: hematoxylin-eosin; original magnification: ×400). (B) Immunohistochemical staining for IgG4 labels most of the plasma cells (IgG immunohistochemical stain counterstained by hematoxylin-eosin; original magnification: ×400).

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Journal of Medical Case Reports

ISSN: 1752-1947