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Figure 9 | Journal of Medical Case Reports

Figure 9

From: A 63-year-old woman presenting with a synovial sarcoma of the hand: a case report

Figure 9

Histological appearance of the tumor. (A) Photomicrograph of a low-power magnification (40×) of a hematoxylin and eosin-stained section showing numerous highly packed cells forming densely cellular sheets and vague fascicles. (B) High-power magnification (400×) photomicrograph showing a hematoxylin and eosin-stained section with spindle cells with oval nuclei and scarce cytoplasm. These cells are uniform and relatively small, characterizing the monophasic “fibrous variant” of synovial sarcoma. (C) High-power magnification (400×) photomicrograph of a hematoxylin and eosin-stained section showing focal areas of a prominent hemangiopericytomatous vascular pattern, which is a frequent finding in synovial sarcoma. (D) Intermediate-power magnification (100×) photomicrograph of a hematoxylin and eosin-stained section showing focal tumor calcifications (arrows), which is also a relatively frequent finding in these tumors. (E) High-power magnification (400×) photomicrograph of an immunohistochemical section marking epithelial membrane antigen outlining the surface of the sarcomatous cells, which is typical of synovial sarcoma. (F) Intermediate-power magnification (100×) photomicrograph of an immunohistochemical section marking cytokeratin 7 (CK7) showing CK7-positive cells either isolated or in cords. (G) High-power magnification (400×) photomicrograph of an immunohistochemical section marking CD99, which is staining the surfaces of tumor spindle cells. (H) High-power magnification (400×) photomicrograph of an immunohistochemical section marking B-cell lymphoma 2 (BCL-2), showing diffuse staining of the tumor.

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