Figure 2

(A1-3) Contrast-enhanced computed tomography scans before restarting sorafenib. (A1, 2) Multiple metastatic lesions were observed in the lung (black arrows). (A3) Local tumor progressions were also observed in the cut surface of the liver (white arrows). (B1-3) Contrast-enhanced computed tomography scans six months after restarting sorafenib. (B1) The growth and new metastatic lesions were observed in the lung (black arrows). (B2) In addition, mediastinal lymph node metastases were observed anew (white arrows). (B3) Local tumor progressions were unequivocally observed (white arrows). (C1-3) Contrast-enhanced computed tomography scans 10 months after restarting sorafenib. (C1) Metastatic lesions in the lung shrunk or disappeared (black arrows). (C2-3) Mediastinal lymph node metastases and local tumor progressions completely disappeared (white arrows).