Supramaximal elevation in B-type natriuretic peptide and its N-terminal fragment levels in anephric patients with heart failure: a case series

Table 2 Available B-type natriuretic peptide, N-terminal fragment, and prolactin results in chronological order

Patient 1 SIA stage	Creatinine, μmol/L	BNP, pmol/L	NT-proBNP, pmol/L	Prolactin, pmol/L
Blood samples (Status)	Creatinine, μmol/L	BNP, pmol/L	NT-proBNP, pmol/L	Prolactin, pmol/L
1 (Pre; +5 months)	630	N/A	N/A	27,561 [13,438]
2 (Pre; +5.5 months)	600	N/A	N/A	41,682 [20,323]
3 (Pre; +8.75 months)	580	9410 [32,563; >400]	N/A	37,398 [18,234]
4 (Post; +8.75 months)	330	5478 [18,958; >400]	N/A	37,923 [18,490]
5 (Pre; +10.75 months)	600	N/A	25,060 [212,370; >1200]	26,868 [13,100]
6 (Post; +10.75 months)	210	N/A	14,814 [125,540; >1200]	18,254 [8,900]
7 (Pre; +5 years)^β	518	N/A	16,846 [142,765; >1200]	8087 [3,943]
^βBlood sample obtained during terminal Event Y. Anti-hypertension methyldopa was ceased for one year prior to this.
Patient 2 SIA stage	Creatinine, μmol/L	BNP, pmol/L	NT-proBNP, pmol/L	Prolactin, pmol/L
Blood samples (Status)	Creatinine, μmol/L	BNP, pmol/L	NT-proBNP, pmol/L	Prolactin, pmol/L
1 (Inter; +1 day)	763	79.2 [274; <225]	N/A	N/A
Patient 2 Post-SIA stage	Creatinine, μmol/L	BNP, pmol/L	NT-proBNP, pmol/L	Prolactin, pmol/L
Blood samples (Status)	Creatinine, μmol/L	BNP, pmol/L	NT-proBNP, pmol/L	Prolactin, pmol/L
1 (Post-Tx; +19 months)	136	52 [180; <201]	32.45 [275; <300]	1103 [538]
Patient 3 SIA stage	Creatinine, μmol/L	BNP, pmol/L	NT-proBNP, pmol/L	Prolactin, pmol/L
Blood samples (Status)	Creatinine, μmol/L	BNP, pmol/L	NT-proBNP, pmol/L	Prolactin, pmol/L
1 (Inter; -7 days)	588	14.8 [51.4; <225]	118.47 [1004; <300]	1389 [677]

(Status): (Pre = 'zenith' pre-dialysis, Inter = 'average' inter-dialysis, Post = 'nadir' post-dialysis, Post-Tx = (successful) post-renal transplant; Timing in relation to Day 0 presentation). N/A = nil available data.
For BNP and NT-proBNP, the two numerical values in parentheses refer to BNP or NT-proBNP values with unit ng/L; reference range to 'rule in' or 'rule out' CHF in unit ng/L as outlined in Table 4 in Discussion section of this article. The different reference range value (<201) quoted in Patient 2 Post-Tx is due to BNP cut-off values to 'rule out' CHF being stratified for GFR. For prolactin, the numerical values in parentheses refer to prolactin values with unit mIU/L with normal range <500 mIU/L.
SIA; Surgically-induced anephric, BNP; B-type natriuretic peptide, NT-proBNP; N-terminal fragment.

ISSN: 1752-1947