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Table 1 Paraneoplastic cerebellar degeneration

From: Anti-Yo and anti-glutamic acid decarboxylase antibodies presenting in carcinoma of the uterus with paraneoplastic cerebellar degeneration: a case report

Date

Fluid

Antibodies

Proteins

Findings

Anti-Yo

Anti-GAD

1 August 2008

Serum

2U (range 0 to 3)

4.3U/mL (<1)

 

Anti-Yo confirmed on immunoblot

CSF

1U

2.0U/mL

14-3-3

 

Serum:CSF ratio = 2:1

Serum:CSF ratio = 2.15:1

  

5 August 2008

 

Intravenous Ig 28 g (0.4 g/kg per day for five days)

   

1 September 2008

 

Laparotomy, hysterectomy, bilateral salpingoophorectomy

   

9 April 2009

Serum

1U

0.2U/mL

  
 

CSF

Undetectable

Undetectable

  

23 December 2009

Serum

0

<0.1U/mL

  

24 December 2010

Serum

0

<0.1U/mL

  

7 November 2011

    

Patient alive; Rankin score 5

  1. Anti-Yo antibodies detected by indirect immunofluorescence on a composite block of primate cerebellum and cerebrum, and mouse stomach (titers expressed 0 = not detected; 1 = weak positive; 2 = moderate positive; 3 = strong positive). GAD antibodies (GAD 65) are measured using a radioimmunoassay and expressed in U/mL (reference range <1).
  2. CSF, cerebrospinal fluid; GAD, glutamic acid decarboxylase.