Figure 1From: Severe brain atrophy after long-term survival seen in siblings with familial amyotrophic lateral sclerosis and a mutation in the optineurin gene: a case series Computed tomography scans of the older sibling. At the age of 45 years (12 years after amyotrophic lateral sclerosis onset; 10 years after the initiation of mechanical ventilation), the scan shows marked brain atrophy. After the subsequent 10 years, whole brain atrophy had markedly progressed. Y-Years; MV-mechanical ventilation.Back to article page