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Table 1 Biochemical data of the four patients treated with cinacalcet.

From: Clinical and biochemical outcomes of cinacalcet treatment of familial hypocalciuric hypercalcemia: a case series

Biochemical data
(normal range)
I-1 I-2 II-1 Case 4
  baseline 1 year baseline 1 year 2 years 3 years baseline 2 months 1 year baseline 1 year 2 years
S-Ca(total) (mmol/L)
2.20 to 2.60
3.01 2.74 3.05 2.58 2.71 2.71 3.02 2.51 NA 3.13 2.86 2.87
B-Ca++ (mmol/L)
1.18 to 1.32
1.61 1.43 1.59 1.46 1.44 1.43 1.54 1.36 1.26 1.81 NA 1.47
S-PTH (pmol/L)
1.6 to 6.9
7.3 7.4 7.1 4.4 3.3 1.9 3.5 6.2 2.9 9.0 8.7 8.3
S-phosphate (mmol/L)
0.76 to 1.41
0.70 0.84 0.83 0.93 1.00 NA 0.76 0.98 NA 0.96 0.93 0.79
S-Mg++ (mmol/L)
0.71 to 94
0.96 0.94 1.12 1.00 0.97 0.97 0.97 0.95 NA 0.99 0.94 0.94
S-creatinine (μmol/L)
50 to 90
55 55 59 52 57 NA 49 NA NA 65 63 60
S-alkaline phosphatase (U/L)
35 to 105
124 142 89 105 94 NA 67 NA NA 76 71 70
S-25(OH)-vitamin D (nmol/L)
50 to 178
38 NA NA NA NA NA 85 NA NA 31 NA NA
BMD             
T-score spine (L1-L4) -3.6 -3.7 -3.1 -3.0 -3.1 -3.0 -0.1 NA NA -0.4 NA -0.7
T-score hip -3.0 -3.0 -2.2 -2.0 -2.0 -2.0 1.5 NA NA 0.3 NA 0.0
  1. I-1, I-2 and II-1 have an R > W substitution in codon 220 and Case 4 has a G > R substitution in codon 613. Data in bold are outside of the reference range. NA: not analyzed.