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Table 5 Plasma protein concentrations and serum chemistries at eight and 12 hours after methadone dosing

From: Methadone adverse reaction presenting with large increase in plasma methadone binding: a case series

Parameter

N

ADR

 

Dose A

Dose B

Dose C

Dose D

Plasma proteins

    

Total protein8 h (g/dL)

5.8

5.8

5.9

7.1

Albumin8 h (g/dL)

3.4

3.5

3.4

3.8

AAG8 h (mg/dL)

84

86

74

87

Total protein12 h (g/dL)

6.3

6.0

6.1

6.9

Albumin12 h (g/dL)

3.5

3.5

3.6

3.8

AAG12 h (mg/dL)

79

81

81

85

Serum chemistries

    

Na+ (mmol/L)

  

144

139

Cl- (mmol/L)

  

108

104

HCO3 - (mmol/L)

  

29

25

Blood urea nitrogen (mg/dL)

  

15

15

Creatinine (mg/dL)

  

0.78

0.72

  1. AAG = α1-acid glycoprotein; ADR = our patient who experienced methadone overexposure; N = our unaffected patient.