Methadone adverse reaction presenting with large increase in plasma methadone binding: a case series

Table 1 Clinical trial design and schedule of activities

	Screening	Period I				Washout period										Period II
Study day	-28 to 0	01	02	03	04	05	06	07	08	09	10	11	12	13	14	15	16	17	18
Electrocardiogram for QT interval	X
Blood draw for screening	X
Methadone dose, 6.0 mg, intravenous		X														X
Letrozole dose, 2.5 mg, orally once a day									X	X	X	X	X	X	X	X	X	X	X
Blood draw for pharmacokinetics		X	X	X	X											X	X	X	X
Urine sampling		X														X

Blood samples (10 mL each) were collected before and at one, two, four, eight, 12, 24, 48 and 72 hours after each methadone dose, except in the second dose for our affected patient from whom blood samples at 48 and 72 hours could not be collected. Urine samples were collected at baseline and over the first 12 hours after methadone dose.

ISSN: 1752-1947