Figure 2From: Methadone adverse reaction presenting with large increase in plasma methadone binding: a case series Plasma methadone concentrations after single intravenous doses administered to both patients. ADR = our patient who experienced methadone overexposure; doses A and C = doses of methadone administered before letrozole treatment; doses B and D = doses of methadone administered after letrozole treatment; N = our unaffected patient.Back to article page