From: Primitive neuroectodermal tumor of the cervix: a case report
First author, year, reference | Age, gravida/para | Clinical stage/metastasis (met) | Treatment protocol | Follow-up |
---|---|---|---|---|
Russin, 1987 [1] | 60 years, 2/2 | IB2/no met | Internal and external RT. Residual carcinoma in endocervical curettement reason for TAH+BSO+staging laparotomy. Tumor in endocervix and implant in cul-de-sac, reason for six courses of CHT. VAC. | Alive 16 months after diagnosis |
Sato, 1996 [2] | 44 years, 4/2 | IB2/no met on whole body X-ray and bone scan negative | TAH+LSO+pelvic lymph node dissection (all N neg), followed by unknown no. of courses of cisplatin, etoposide, adriamycin and cyclophosphamide. Second-look operation after 6 months revealed no tumor. | Alive 6 months after first operation |
Horn, 1997 [3] | 26 years, 3/2 | IB1/no met after hysterectomy | TAH+BSO+pelvic lymphadenectomy (lymphangiosis but no met) followed by RT of the pelvis 3 years later, pulmonary met: CHT (5 FU/cisplatin)+thorax RT. | Died 4.2 years after surgery, due to met |
Cenacchi, 1998 [4] | 36 years | IB2/no met on whole body CT after TAH | TAH without BSO | Alive NED 18 months after surgery |
Pauwels, 2000 [5] | 45 years | IB2/no met | TAH (no tumor outside the cervix) followed by pelvic RT | Alive 42 months after surgery |
Tsao, 2001 [6] | 24 years, 3/2 pregnant | No bony lesions and no lymph node involvement | Pre-operative CHT due to large primary lesion: two alternating cycles of VAC and IE, followed by TAH+transposition of the ovaries and para-aortic LN sampling, followed by two alternating cycles of VAC and IE, and then pelvic RT. | No details of survival |
Malpica, 2002 [7] | 35 years | IB1/no met | TAH+BSO+selective para-aortic and bilateral pelvic lymphadenectomy followed by adjuvant CHT | Alive 5 months after diagnosis |
Malpica, 2002 [7] | 51 years | IB2/no met | Same treatment as the previous patient | Alive 18 months after diagnosis |
Snijders-Keilholz, 2005 [9] | 21 years, nulligravid | -/no met | Six courses of DIME followed by hysterectomy without adnexectomy and without lymphadenectomy followed by 5 courses of VIA | Alive 27 months after diagnosis |
Goda, 2007 [8] | 19 years, nulligravid | -/no met | Combination CHT with VAC, planned for further consolidation CHT after RT | Alive |