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Table 1 Management of nine patients with primitive neuroectodermal tumor (PNET) of the cervix, as published in the English literature (1987 to 2008)

From: Primitive neuroectodermal tumor of the cervix: a case report

First author, year, reference Age, gravida/para Clinical stage/metastasis (met) Treatment protocol Follow-up
Russin, 1987 [1] 60 years, 2/2 IB2/no met Internal and external RT. Residual carcinoma in endocervical curettement reason for TAH+BSO+staging laparotomy. Tumor in endocervix and implant in cul-de-sac, reason for six courses of CHT. VAC. Alive 16 months after diagnosis
Sato, 1996 [2] 44 years, 4/2 IB2/no met on whole body X-ray and bone scan negative TAH+LSO+pelvic lymph node dissection (all N neg), followed by unknown no. of courses of cisplatin, etoposide, adriamycin and cyclophosphamide. Second-look operation after 6 months revealed no tumor. Alive 6 months after first operation
Horn, 1997 [3] 26 years, 3/2 IB1/no met after hysterectomy TAH+BSO+pelvic lymphadenectomy (lymphangiosis but no met) followed by RT of the pelvis 3 years later, pulmonary met: CHT (5 FU/cisplatin)+thorax RT. Died 4.2 years after surgery, due to met
Cenacchi, 1998 [4] 36 years IB2/no met on whole body CT after TAH TAH without BSO Alive NED 18 months after surgery
Pauwels, 2000 [5] 45 years IB2/no met TAH (no tumor outside the cervix) followed by pelvic RT Alive 42 months after surgery
Tsao, 2001 [6] 24 years, 3/2 pregnant No bony lesions and no lymph node involvement Pre-operative CHT due to large primary lesion: two alternating cycles of VAC and IE, followed by TAH+transposition of the ovaries and para-aortic LN sampling, followed by two alternating cycles of VAC and IE, and then pelvic RT. No details of survival
Malpica, 2002 [7] 35 years IB1/no met TAH+BSO+selective para-aortic and bilateral pelvic lymphadenectomy followed by adjuvant CHT Alive 5 months after diagnosis
Malpica, 2002 [7] 51 years IB2/no met Same treatment as the previous patient Alive 18 months after diagnosis
Snijders-Keilholz, 2005 [9] 21 years, nulligravid -/no met Six courses of DIME followed by hysterectomy without adnexectomy and without lymphadenectomy followed by 5 courses of VIA Alive 27 months after diagnosis
Goda, 2007 [8] 19 years, nulligravid -/no met Combination CHT with VAC, planned for further consolidation CHT after RT Alive
  1. CHT = chemotherapy; CT = computed tomography; DIME = doxorubicin, Ifosfamide, mesna, etoposide; IE = ifosfamide, etoposide; N neg = lymph node negative; NED = no evidence of disease; RT = radiotherapy; TAH+BSO = total abdominal hysterectomy, bilateral salpingo-oophorectomy; VAC = vincristine, adriamycin, cyclophosphamide; VID = vincristine, ifosfamide, dactinomycin.