Table 3 Naranjo scale
From: Cardiac arrest provoked by itraconazole and amiodarone interaction: a case report
Questionnaire question and answer scoring | Answer/score |
|---|---|
1. Are there previous conclusive reports on this reaction? | No (0) |
Yes (+1); no (0); do not know or not done (0) | Â |
2. Did the adverse event appear after the suspected drug was given? | Yes (+2) |
Yes (+2); no (-1); do not know or not done (0) | Â |
3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was given? | Yes (+1) |
Yes (+1); no (0); do not know or not done (0) | Â |
4. Did the adverse reaction appear when the drug was readministered? | Yes (+2) |
Yes (+2); no (-2); do not know or not done (0) | Â |
5. Are there alternative causes that could have caused the reaction? | No (+2) |
Yes (-1); no (+2); do not know or not done (0) | Â |
6. Did the reaction reappear when a placebo was given? | No (+1) |
Yes (-1); no (+1); do not know or not done (0) | Â |
7. Was the drug detected in any body fluid in toxic concentrations? | No (0) |
Yes (+1); no (0); do not know or not done (0) | Â |
8. Was the reaction more severe when the dose was increased, or less severe when the dose was decreased? | Yes (+1) |
Yes (+1); no (0); do not know or not done (0) | Â |
9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure? | No (0) |
Yes (+1); no (0); do not know or not done (0) | Â |
10. Was the adverse event confirmed by any objective evidence? | No (0) |
Yes (+1); no (0); do not know or not done (0) | Â |
Scoring: | Â |
>9 = definite adverse drug reaction (ADR), 5-8 = probable ADR, 1-4 = possible ADR, 0 = doubtful ADR | 9 = definite ADR |