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Table 1 Paraneoplastic syndromes associated with small cell lung cancera

From: Dual paraneoplastic syndromes in a patient with small cell lung cancer: a case report

  Ectopic hormone-associated syndromes Immune-mediated neurologic syndromes
Clinical syndrome Incidence SCLC hormone Incidence Antibody SCLC-expressed gene or protein
Ectopic Cushing's syndrome 5% ACTH    
Hyponatremia of malignancy 15% AVP, CRH (rare)    
Hypertension <1% Renin    
Amenorrhea, galactorrhea <1% Prolactin, GH    
Hyperamylasemia <1% Salivary anylase    
Lambert-Eaton myasthenic
syndrome
   1% Anti-VGCC Synaptotagmin, MysB
Encephalomyelitis    <1% Anti-Hu HuD, HuC, Hel-N1, N2
Sensory neuropathy    <1% Anti-Hu HuD, HuC, Hel-N1, N2
Cerebellar degeneration    <1% Anti-Hu HuD, HuC, Hel-N1, N2
     Anti-VJCC, MysB Synaptotagmin
     Anti-Ri Nova-1
     Anti-Yo CDR-34
Retinopathy    <1% Anti-CAR Recoverin
Stiff-person syndrome
(encephalitis)
   <1% Anti-amphiphysin Amphiphysin
Opsoclonus, myoclonus    <1% Anti-Hu HuD, HuC, Hel-N1, N2
     Anti-Ri Nova-1
      HuD, HuC, Hel-N1, N2
      Synaptotagmin
      Nova-1
  1. aSCLC, small cell lung cancer; ACTH, adrenocorticotropin hormone; AVP, arginine vasopressin; CRH, corticotropin-releasing hormone; GH, growth hormone; VGCC, voltage-gated calcium channel; MysB,; HuD, Human Neuronal Protein D; HuC, Human Neuronal Protein C; Hel-N1,; VJCC,; Ri,; Yo,; CDR-34,; anti-CAR, anti-coxsackie adenovirus receptor.
  2. Reprinted with permission from Gandhi L, Johnson BE: Paraneoplastic syndromes associated with small cell lung cancer. J Natl Compr Canc Netw 2006, 4: 631-638 [12].