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Renal cell carcinoma metastasizing to solitary fibrous tumor of the pleura: a case report
© Kragel and Wei; licensee BioMed Central Ltd. 2011
Received: 6 December 2010
Accepted: 29 June 2011
Published: 29 June 2011
A tumor metastasizing to another malignancy is an uncommon phenomenon. Since it was first described in 1902, there have been fewer than 200 cases reported in the literature, with lung cancer metastasizing to renal cell carcinoma being the most frequently described pattern. Here we report a case of a solitary fibrous tumor of the lung acting as the recipient for a renal cell carcinoma. To our knowledge, this is the first reported case of such a combination and the second case involving a solitary fibrous tumor.
A 58-year-old Caucasian man who developed a persistent dry cough presented to our hospital. Imaging studies revealed a large pleural-based mass in the left lung. A biopsy of the mass showed a spindle-cell lesion consistent with a solitary fibrous tumor. The patient underwent surgical excision of the 13 cm mass. The pathological examination confirmed the diagnosis of a solitary fibrous tumor but also demonstrated discrete foci of metastatic renal cell carcinoma. Until that point, a primary renal cell carcinoma tissue diagnosis had not been made and the initial radiological work-up was inconclusive.
Awareness of the unusual phenomenon of tumor-to-tumor metastasis is important for practicing surgical pathologists, particularly in the evaluation of a mass lesion showing bimodal histology. This case also highlights the importance of careful examination of surgical specimens, as minute and unusual findings can direct patient care.
The coexistence of two primary neoplasms in one patient is not uncommon, and these tumors may even arise at the same anatomic site ("collision tumor"). However, tumor-to-tumor metastasis is an extremely rare but interesting phenomenon. Since first described by Berent in 1902 , fewer than 200 cases have been reported in the English-language literature. The most frequent donor tumor site is the lung, while renal cell carcinoma is by far the most common recipient [2, 3]. This combination constitutes approximately one-third of all reported cases. However, renal cell carcinoma acting as a donor tumor is extraordinarily rare, with only nine cases reported to date [4–12]. Interestingly, meningiomas are the most frequent recipients of donor renal cell carcinoma, followed by papillary carcinoma of the thyroid. Here we report the first case of a solitary fibrous tumor of the lung acting as the recipient of a donor renal cell carcinoma.
Within the solitary fibrous tumor, there were two microscopic foci of nested epithelioid cells with clear cell features in the background of a delicate vascular network (Figures 3b and 3c). To further explore the nature of these cells, a battery of immunohistochemical staining was performed. The cells of interest were positive for broad-spectrum cytokeratin (Figure 3e) and vimentin (Figure 3f) and were also immunoreactive with CD10 (Figure 3g) and paired box gene 2 (PAX2) (Figure 3h). Thus, these cells most likely represented metastatic clear cell renal cell carcinoma. One lymph node showed necrotizing granulomata, but all thoracic nodes were negative for malignancy.
Post-operatively, a multidisciplinary team weighed the treatment options. However, in the coming months, further imaging analysis revealed additional metastases to the liver, spine and brain. The patient underwent chemotherapy, spinal radiation therapy and gamma knife radiosurgery for brain metastasis. With metastatic disease causing increased morbidity and no further treatment options available, the patient was placed in hospice care and died within six months of the initial diagnosis.
In 1968, Campbell et al.  reviewed previously reported cases and asserted the criteria for tumor-to-tumor metastasis as follows: (1) the existence of more than one primary tumor, (2) the recipient tumor is a true neoplasm, (3) the donor tumor is a true metastasis with established growth in the host tumor that is not the result of contiguous growth ("collision tumor") or embolization of tumor cells and (4) tumors that have metastasized to the lymphatic system, where a lymphoreticular malignant tumor already exists, are excluded. Thus, our present case meets these criteria.
Virtually any tumor may become a potential recipient of a donor metastatic tumor, but renal cell carcinoma is by far the most common one [2, 3]. This is likely because kidneys receive significant blood flow and renal cell carcinoma is typically vascularly rich and thus easily harbors circulating tumor emboli [2, 3]. It has also been suggested that the high glycogen and lipid content of carcinoma cells may serve as a suitable environment for metastatic deposits  and thus may reflect the "seed and soil" hypothesis of cancer metastasis . A solitary fibrous tumor is extraordinary rare as a recipient tumor, and our present case report represents only the second reported such case. The tumor typically has alternating hypercellular and hypocellular areas and characteristic branching, staghorn vessels which may captivate blood-borne metastases, as in the case of renal cell carcinomas.
As a donor tumor, however, renal cell carcinoma is extremely uncommon, with only nine cases reported in the literature to date. All four patients with known follow-up died of the disease [4, 6–8], which is compatible with the significantly unfavorable prognosis of other stage IV renal cell carcinomas. Interestingly, tumors of central nervous system [4, 5, 7, 9, 12] and thyroid carcinomas [8, 10, 11] represent frequent recipient tumors for donor renal cell carcinomas, suggesting that these organs and tumoral tissues may provide a fertile substrate or are some way predisposed targets for secondary growth of renal cell carcinoma.
The diagnosis of renal cell carcinoma metastasizing to solitary fibrous tumor is paramount in this case as the metastasis was the first confirmation of renal cell carcinoma in this patient. Retrospectively, the renal cysts identified in the initial radiological work-up may represent cystic renal cell carcinoma. This case exemplifies the importance of careful scrutiny of the pathologic specimens because rare or unusual pathologic findings may be of utmost clinical importance. In addition, our present case report also emphasizes the need for adequate sampling (that is, one section per centimeter of tumor mass), as only one of the 14 sections of the tumor possessed small metastatic foci.
Awareness of the unusual phenomenon of tumor-to-tumor metastasis is important for practicing surgical pathologists, particularly in the evaluation of a mass lesion showing bimodal histology. This case also highlights the importance of careful examination of surgical specimens, as minute and unusual findings can direct patient care. Moreover, the relative frequency of specific neoplasms involved in tumor-to-tumor metastasis may shed light on the pathogenesis of tumor metastasis.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Berent W: Seltene metastasenbildung. Zentralbl Allg Pathol. 1902, 13: 5.Google Scholar
- Petraki C, Vaslamatzis M, Argyrakos T, Petraki K, Strataki M, Alexopoulos C, Sotsiou F: Tumor to tumor metastasis: report of two cases and review of the literature. Int J Surg Pathol. 2003, 11: 127-135. 10.1177/106689690301100214.View ArticlePubMedGoogle Scholar
- Sella A, Ro JY: Renal cell cancer: best recipient of tumor-to-tumor metastasis. Urology. 1987, 30: 35-38. 10.1016/0090-4295(87)90568-1.View ArticlePubMedGoogle Scholar
- Osterberg DH: Metastases of carcinoma to meningioma. J Neurosurg. 1957, 14: 337-343. 10.3171/jns.1957.14.3.0337.View ArticlePubMedGoogle Scholar
- Breadmore R, House R, Gonzales M: Metastasis of renal cell carcinoma to a meningioma. Australas Radiol. 1994, 38: 144-3. 10.1111/j.1440-1673.1994.tb00157.x.View ArticlePubMedGoogle Scholar
- Ozenc A, Ruacan S, Baykal A: Renal cell carcinoma and ipsilateral pheochromocytoma with neoplasm-to-neoplasm metastasis. J Urol. 1997, 157: 1831-1832. 10.1016/S0022-5347(01)64871-7.View ArticlePubMedGoogle Scholar
- Franke FE, Altmannsberger M, Schachenmayr W: Metastasis of renal carcinoma colliding with glioblastoma. Carcinoma to glioma: an event only rarely detected. Acta Neuropathol. 1990, 80: 448-452. 10.1007/BF00307701.View ArticlePubMedGoogle Scholar
- Baloch ZW, LiVolsi VA: Tumor-to-tumor metastasis to follicular variant of papillary carcinoma of thyroid. Arch Pathol Lab Med. 1999, 123: 703-706.PubMedGoogle Scholar
- Han HS, Kim EY, Han JY, Kim YB, Hwang TS, Chu YC: Metastatic renal cell carcinoma in a meningioma: a case report. J Korean Med Sci. 2000, 15: 593-597.View ArticlePubMedPubMed CentralGoogle Scholar
- Ryska A, Cáp J: Tumor-to-tumor metastasis of renal cell carcinoma into oncocytic carcinoma of the thyroid: report of a case and review of the literature. Pathol Res Pract. 2003, 199: 101-106.PubMedGoogle Scholar
- Bohn OL, De las Casas LE, Leon ME: Tumor-to-tumor metastasis. Renal cell carcinoma metastatic to papillary carcinoma of thyroid: report of a case and review of the literature. Head Neck Pathol. 2009, 3: 327-330. 10.1007/s12105-009-0147-9.View ArticlePubMedPubMed CentralGoogle Scholar
- Kimiwada T, Motohashi O, Kumabe T, Watanabe M, Tominaga T: Lipomatous meningioma of the brain harboring metastatic renal-cell carcinoma: a case report. Brain Tumor Pathol. 2004, 21: 47-52. 10.1007/BF02482177.View ArticlePubMedGoogle Scholar
- Campbell LV, Gilbert E, Chamberlain CR, Watne AL: Metastases of cancer to cancer. Cancer. 1968, 22: 635-643. 10.1002/1097-0142(196809)22:3<635::AID-CNCR2820220320>3.0.CO;2-O.View ArticlePubMedGoogle Scholar
- Ottosson L, Berge T: Metastasis from carcinoma to carcinoma. Acta Pathol Microbiol Scand. 1968, 73: 481-488.View ArticlePubMedGoogle Scholar
- Paget S: The distribution of secondary growths in cancer of the breast. Lancet. 1889, 133: 571-573. 10.1016/S0140-6736(00)49915-0.View ArticleGoogle Scholar
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