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Table 1 Review of the clinical characteristics, treatment and outcome of the reported adult patients in the English literature with Brucellosis-related pericarditis and/or myocarditis in the absence of concomitant endocarditis.

From: Unusual cardiovascular complications of brucellosis presenting in two men: two case reports and a review of the literature

Publication (Ref)

Cases, n

Clinical presentation

ECG

Echocardiography

Serum agglutination test

Cultures

Pericarditis

Myocarditis

Treatment

Outcome

Pandit et al., 2010 [21]

1

Fever, dyspnea, constitutional symptomsa

Sinus tachycardia

Abnormal

1:1280

Positive

No

Yes

Streptomycin, doxycycline

Death

Efe et al., 2009 [17]

1

Dyspnea

ST-depression T-wave inversion

Diffuse hypokinesia and ventricular dilatation (10-15% ejection fraction)

1:5120

Positive

No

Yes

Streptomycin (3 weeks, doxycycline (6 weeks

Cure

Khorvash et al., 2007 [20]

1

Fever, constitutional symptoms

Sinus bradycardia High T-waves

Septal hypokinesia, 30% ejection fraction

1:80

Positive

No

Yes

Doxycycline (6 weeks, rifampicin (6 weeks

Relapse

Hatipoglu et al., 2004 [14]

2

Dyspnea, arthritis, constitutional symptoms

NA

Pericardial effusion

1:320

Positive

Yes

No

Doxycycline (6 months), ofloxacin (6 months), rifampicin (6 months)

Cure

  

Fever, dyspnea, retrosternal pain

NA

Pericardial effusion

1:640

Negative

Yes

No

Gentamicin (2 weeks, doxycycline (6 weeks, ciprofloxacin (6 weeks

Cure

Karagiannis et al., 2003 [22]

1

Fever, dyspnea

Atrial fibrillation

Large pericardial effusion

1:1280

Negativeb

Yes

No

Streptomycin (2 weeks, doxycycline (6 weeks, indomethacin (2 weeks

Cure

Colmenero et al., 1996 [2]

2c

NA

NA

NA

NA

NA

Yes

Yes

Na

NA

Jubber et al., 1990 [23]

1d

Fever, dyspnea, constitutional symptoms

T-wave inversion

Moderate hypokinesia of interventricular septum and posterior wall of left ventricle

Negative

NA

No

Yes

Vibramycin, rifampicin

Cure

Rivera et al., 1988 [24]

1

Fever, chest pain, pericardial friction rub

NA

Moderate pericardial effusion

1:640

Positive

Yes

No

Rifampicin, doxycycline

Cure

Lulu et al., 1988 [19]

1e

NA

NA

NA

NA

NA

No

Yes

NA

NA

Ugartemendia et al., 1985 [12]

2

Fever, chest pain

NA

Severe pericardial effusion in both (tamponade)

1:320, 1:640

Positive

Yes

No

Cotrimoxazole, streptomysin, oxytetracycline

1 death, 1 cure

Gur et al., 1984 [25]

1

High remittent fever

Negative, biphasic or flat T-waves

NA

1:6400

Positive

No

Yes

Streptomycin (2 weeks, tetracycline (4.5 weeks

Relapse

  1. aConstitutional symptoms include sweating, malaise, anorexia, weight loss, arthralgias, myalgias.
  2. bThis patient was already receiving antibiotic treatment.
  3. cTwo out of a series of 530 patients (one patient had pericarditis and one myocarditis).
  4. dDiagnosis based on high titers of antibodies by ELISA.
  5. eOne out of 400 cases of brucellosis.
  6. NA = not available.