Case report | Patient and history | PS | Trigger | Treatment (target levels)b | Outcome and treatmentc |
---|---|---|---|---|---|
Boccara et al. [15] | Two-year-old girl Varicella three months prior | Low | HHV-6 | IVIg 2 g/kg, LMWH, plasmapheresis q12 h, FFP (repeat IVIg if PS < 50%) | Pre-treatment: right leg amputation Post-treatment: resolution, IVIg 2 ×/day |
Özbek et al. [9] | Eight-year-old boy FVL+/- G20210A+/- | Low | Not known | Prior treatment: SQ UH, IV ceftriaxone, metronidazole (One) Bolus 75U UH, 15 days continuous 20 U/kg/hour, twice daily FFP × 5 daysb (Two) 80 to 100 U/kg SQ heparin for 1 month (Three) Warfarin (INR Two or Three) | Pre-treatment: necrosis in lower half of body Post-treatment: resolution |
al-Ismail et al. [10] | 4.8-year-old boy G20120A+/- ANA+ ASO+ Viral titer- | Low | Streptococcus? | (One) Antibiotics, FFP, vitamin K (Two) IV UH (aPTT 1.5-2.5 × normal)b (Three) Enoxaparin 20 mg/q12 hours (anti-Xa level 0.6 U/L) | Pre-treatment: left leg swelling, edema, left femoral vein thrombosis Post-treatment: resolution |
Levin et al.d [7] | 6.4-year-old boy Varicella One year prior | Low | Fever, vesicular rash | (One) IV penicillin, cefotaxime, 4U FFP, IVIg 1 g/kg, exchange transfusion, methylprednisone, IV heparin 15 U/kg/hour, tPa for PE, prostacyclin (Two) IV heparin increased to 60 U/kg/hour, FFP 40 mL/kg/day (aPTT 1.5 to 2.5 × normal)b (Three) Warfarin | Pre-treatment: lesions stopped, right leg amputation, PE1 Post-treatment: then respiratory improvement, resolution |
 | 5.9-year-old girl | Low | Varicella | (One) IV cefotaxime, acyclovir and heparin bolus 100 U/kg/hour, then 25 U/kg/hour; two volume exchange transfusion, then daily FFP | Pre-treatment: right atrial thrombosis, PEe Post-treatment: skin grafting |