Empiric treatment of protracted idiopathic purpura fulminans in an infant: a case report and review of the literature

Table 2 Differential diagnosis of necrotic skin lesions in an infant^a

System	Diagnoses
Hematologic	Idiopathic thrombocytopenic purpura Thrombotic thrombocytopenic purpura Coagulation factor deficiency Platelet function disorder Thromboembolic disease Lupus/anti-phospholipid antibodies Cryoglobulinemia Porphyria Idiopathic red blood cell agglutination Idiopathic PF Neonatal PF or other thrombophilic mutation
Infectious	Cellulitis with or without atypical organisms or fungi Endocarditis (bacterial, fungal or marantic)
Inflammatory	Panniculitis secondary to α₁-anti-trypsin deficiency Pemphigus vulgaris Pyoderma gangrenosum Epidermolysis
Vascular	HSP Leukocytoclastic vasculitis Hematoma with compartment syndrome
Neoplastic	Leukemia Lymphoma Essential thrombocythemia Cutaneous T-cell lymphoma
Nutritional	Vitamin deficiency (vitamin K) Mineral deficiency (zinc)
Environmental	Toxic exposure (for example, heavy metals)
Congenital	Combined immune deficiency Prolidase deficiency Leukocyte adhesion deficiency Chronic granulomatous disease γ-globulinemia Spinal muscular atrophy
Trauma

ISSN: 1752-1947