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Table 1 Laboratory evaluation at first admission, dismissal and second admissiona

From: Empiric treatment of protracted idiopathic purpura fulminans in an infant: a case report and review of the literature

Test or laboratory evaluation

Admission 1 (dismissal 1)b

Admission 2

Reference range

Hemoglobin

13.1 (9.6c)g/dL

11.5 g/dL

10.5 to 13.5 g/dL

Hematocrit

37.5 (27.6c)%

34.0%

33.0% to 44.0%

Leukocytes

16.5c (15.7c) × 109/L

26.3 × 109/Lc

6 to 11 × 109/L

Thrombocytes

738c (651c) × 109/L

951 × 109/Lc

150 to 450 × 109/L

Neutrophils

11.41c (6.47) × 109/L

-

1.5 to 8.5 × 109/L

Lymphocytes

3.91c (7.65) × 109/L

-

4.0 to 10.5 × 109/L

Monocytes

1.09 (1.42c) × 109/L

-

0.05 to 1.1 × 109/L

Eosinophils

0.00c (0.05) × 109/L

-

0.05 to 0.7 × 109/L

PT

9.8 seconds

9.6 seconds

8.3 to 10.8 seconds

aPTT

30 seconds

30 seconds

21 to 33 seconds

Thrombin time

20 seconds

22 seconds

16 to 25 seconds

Protein C, activity

99%

120%

70% to 150%, adults

Protein S, free

116

144

65% to 160%, men

Protein S, activity

123%

123%

65% to 160%, adults

Anti-thrombin activity

119%

136%c

80% to 130%, > 6 months old

D-dimer

 

200 ng/mL

< 250 ng/mL

Fibrinogen

315 mg/dL

351 mg/dL

200 to 375 mg/dL

DRVVT

 

1.0

< 1.2

APC ratio

 

3.1

> 2.3

Factor VIII

 

170%

55% to 205%, adults

Ristocetin co-factor

 

92%

55% to 200%, adults

von Willebrand factor

 

112%

-

ESR

11 mm/hour

25 mm/hour

-

CRP

5.6 mg/L

9.1 mg/Lc

< 8.0 mg/L

ANA antibody

0.1 U

 

< 1.0

Homocysteine

7 μmol/L

5 μmol/L

< 13 μmol/L

Anti-phospholipid/anti-cardiolipin, IgM

< 4.0

 

-

-IgG

< 4.0

 

-

AST

27 U/Lc

24 U/L

8 to 20 U/L

ALT

18 U/L

15 U/L

8 to 20 U/L

ACE

16 U/L

 

8 to 53 U/L

Cryofibrinogen

Neg

 

Neg

Cryoglobulin

Neg

 

Neg

Plasma porphyrins

< 1 U/L

 

< 1 U/L

RBC ALA dehydratase

8.7 nmol/L/second

 

-

Myeloperoxidase

< 0.2 U

< 0.2 U

< 0.4 U

Proteinase 3

< 0.2 U

< 0.2 U

< 0.4 U

Total protein

5.3 g/dLc

 

6.0 to 7.8 mg/dL

Albumin

3.0 g/dLc

 

3.5 to 5.5 mg/dL

Sodium ion

 

138 mmol/L

135 to 145 mmol/L

Potassium ion

 

5.2 mmol/Lc

3.5 to 5.0 mmol/L

Bicarbonate ion

 

19 mmol/L

18 to 23 mmol/L

Chloride

 

105 mmol/L

95 to 105 mmol/L

BUN

 

9 mg/dLc

3 to 7 mmol/L

Creatinine

 

0.2 mg/dLc

0.7 to 1.0 mg/dL

GGT

 

19 U/L

5 to 40 U/L

Anion gap

 

14 mEq/Lc

8 to 12 mEq/L

Glucose

 

107 mg/dLc

70 to 99 mg/dL

Bilirubin (total/direct)

 

0.2/0.1 mg/dL

0.1 to 1.0/0.0 to 0.3 mg/dL

IgM

80 mg/dL

67 mg/dL

24 to 267 mg/dL

IgG

272 mg/dL

289 mg/dL

164 to 588 mg/dL

IgA

 

130 mg/dLc

16 to 50 mg/dL

IgE

 

7.5 kU/L

< 30 kU/L

Complement C3

 

128 mg/dL

75 to 175 mg/dL

-C4

 

134 mg/dLc

14 to 40 mg/dL

Fc C7

 

59 U/mL

36 to 60 U/mL

-C8

 

60 U/mLc

33 to 58 U/mL

-C9

 

61 U/mL

37 to 61 U/mL

β2 microglobulin

 

5.6 μg/mL

0.70 to 1.80 μg/mL

Zinc

 

0.67 μg/mL

0.6 to 1.20 μg/mL

α1-anti-trypsin

 

144 mg/dL

89 to 230 mg/dL

Cold agglutinin

(Negative)

  

Mycoplasma IgM

0.10

 

< 0.90

-IgG

0.5

 

-

  1. aPT, prothrombin time; aPTT, activated partial thromboplastin time; DRVVT, dilute Russell's viper venom test; APC, activated protein C; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; ANA, anti-nuclear; IgM, immunoglobulin M; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ACE, angiotensin-converting enzyme; RBC ALA, red blood cell Δ-aminolevulinic acid; BUN, blood urea nitrogen; GGT, γ-glutamyl transferase; Fc, functional component; bvalues in parentheses are those which occurred at first discharge, which was approximately one week after first admission. The second admission occurred 1 week after the first discharge. coutside normal limits.