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Table 2 Treatment management of ECF and outcomes

From: Adalimumab - an effective and promising treatment for patients with fistulizing Crohn's disease: a case series

Treatment

ECF outcome

SOWATS treatment guideline (medical + surgical treatment)

Mortality: 10-30%

Fistula closure: ~87,4%

Medical treatment

Alimentary tract rest

Restoration of circulating volume

Restoration of hydroelectrolytic balance

Nutritional support (optimal TPN)

(fistula closure rate: 89-92,3%)

Controlling sepsis

Wound care

Mortality: 5-25%

Spontaneous closure: 17-71%

Restorative surgery

Minimal period: >6 weeks

Mortality: 9,6%-10,8%

(sepsis-related death: ~15,1%)

Surgical closure: 52-90,7%

Persisting fistula: 3-50%

Definitive surgery

Minimal period: >6 months

(median period: 8 months)

 

Small bowel ECF

Mortality: ~35%

Spontaneous closure: ~30%

Colonic ECF

Mortality: ~22%

Spontaneous closure: ~85%

  1. References: [12–15]