Table 1 Cases of neurobrucellosis with intracerebral granuloma.
Author/year | Signs and symptoms | Age/sex | Lesion | Analysis of granuloma, blood, CSF samples | Treatment/duration/result |
|---|---|---|---|---|---|
Ciftci et al. [10] 1998 | Visual impairment, bilateral hearing loss, hyperprolactinemia, meningitis | 25-year-old female | Sellar and suprasellar mass | STA, 1/320, and 1/160 in blood and CSF, respectively 190 cells/mL (lymphocytes), protein 227 mg/dL, glucose 18 mg/dL in CSF | TS, RIF, 10 weeks, hearing loss |
Sohn et al. [11] 2003 | Periorbital pain, headache, generalized tonic-clonic seizure | 26-year-old man | 3 × 3 cm left frontal lobe mass | Brucella spp. in granuloma culture STA, 1/160, in blood | Surgery + TS, RIF, 2 months, recovery |
Headache, nausea, vomiting, progressive visual function deterioration | 15-year-old boy | Granulomas in the left occipital and parietal lobes (TI+contrast) | Brucella spp. in granuloma culture Serology:negative | DS,RIF, GM (1 month and then TMP/SMX), 1 year, visual acuity deficits and brain atrophy | |
Al-Sous et al. [13] 2004 | Headache, deafness, papilledema, sensory ataxia, areflexia | 30-year-old female | Enhancing granuloma suprasellar region(TI+contrast) | STA, 1/1280, 2ME, 1/640, in CSF Protein level: 80 mg/dL in CSF | DS,RIF, TMP/SMX, 4 months, complete recovery |
Miguel et al. [12] 2006 | Weakness of the right upper and lower limbs, headache, Broca's aphasia | 39-year-old male | 3 cm enhancing mass lesion in the left parietal lobe (T1,T2 + contrast) | IgM and IgG antibodies by ELISA in CSF and blood 10 cells (mostly lymphocytes), protein 76 mg/dL, glucose 55 mg/dL in CSF | DS, RIF, GM, 2 months, right hemiparesis |
Present case | Headache, weakness in the left arm, hypoesthesia, speech disturbance, imbalance, fever, diplopia, 6.7.cranial nerves involvement, generalized tonic-clonic seizures | 17-year-old boy | A granuloma in the genus of the right capsula interna (T1-contrast) | IgM and IgG antibodies by ELISA i n the CSF and blood STA, 1/160, and 1/80 in blood and CSF, respectively 104 cells (lymphocytes, 86%), protein 250 mg/dL, glucose 22 mg/dlL in CSF | DS, RF, TMP/SMX, 6 months, complete recovery |