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Table 1 Cases of neurobrucellosis with intracerebral granuloma.

From: Neurobrucellosis with transient ischemic attack, vasculopathic changes, intracerebral granulomas and basal ganglia infarction: a case report

Author/year Signs and symptoms Age/sex Lesion Analysis of granuloma, blood, CSF samples Treatment/duration/result
Ciftci et al. [10] 1998 Visual impairment, bilateral hearing loss, hyperprolactinemia, meningitis 25-year-old female Sellar and suprasellar mass STA, 1/320, and 1/160 in blood and CSF, respectively
190 cells/mL (lymphocytes), protein 227 mg/dL, glucose 18 mg/dL in CSF
TS, RIF, 10 weeks, hearing loss
Sohn et al. [11] 2003 Periorbital pain, headache, generalized tonic-clonic seizure 26-year-old man 3 × 3 cm left frontal lobe mass Brucella spp. in granuloma culture STA, 1/160, in blood Surgery + TS, RIF, 2 months, recovery
  Headache, nausea, vomiting, progressive visual function deterioration 15-year-old boy Granulomas in the left occipital and parietal lobes (TI+contrast) Brucella spp. in granuloma culture Serology:negative DS,RIF, GM (1 month and then TMP/SMX), 1 year, visual acuity deficits and brain atrophy
Al-Sous et al. [13] 2004 Headache, deafness, papilledema, sensory ataxia, areflexia 30-year-old female Enhancing granuloma suprasellar region(TI+contrast) STA, 1/1280, 2ME, 1/640, in CSF Protein level: 80 mg/dL in CSF DS,RIF, TMP/SMX, 4 months, complete recovery
Miguel et al. [12] 2006 Weakness of the right upper and lower limbs, headache, Broca's aphasia 39-year-old male 3 cm enhancing mass lesion in the left parietal lobe (T1,T2 + contrast) IgM and IgG antibodies by ELISA in CSF and blood
10 cells (mostly lymphocytes), protein 76 mg/dL, glucose 55 mg/dL in CSF
DS, RIF, GM, 2 months, right hemiparesis
Present case Headache, weakness in the left arm, hypoesthesia, speech disturbance, imbalance, fever, diplopia, 6.7.cranial nerves involvement, generalized tonic-clonic seizures 17-year-old boy A granuloma in the genus of the right capsula interna (T1-contrast) IgM and IgG antibodies by ELISA i n the CSF and blood STA, 1/160, and 1/80 in blood and CSF, respectively
104 cells (lymphocytes, 86%), protein 250 mg/dL, glucose 22 mg/dlL in CSF
DS, RF, TMP/SMX, 6 months, complete recovery
  1. Abbreviations DS: doxycyline; GM: gentamycine; RIF: rifampicin; TMP/SMX: trimethoprim/sulfamethoxazole; TS: tetracycline.