Pathological features | Secondary | Primary |
---|---|---|
Gross | ||
Bilaterality | ✓ | |
Surface implants | ✓ | |
Multinodular growth | ✓ | |
Size > 10 cm | ✓ | ✓ |
Smooth tumor surface | ✓ | |
Mural nodule | ✓ | |
Micro | ||
Surface implants in the form of irregular/dilated/cystic/angulated/tubular glands/cell nests or single tumor cells within a desmoplastic/hyalinized stroma | ✓ | |
Infiltrative pattern (disorderly penetration of the stroma by small glands, tubules, or single cells, including signet-ring cells, usually within a desmoplastic stroma) | ✓ | |
Growth in the ovarian hilum | ✓ | |
Foci of uninvolved ovarian tissue | ✓ | |
Mucin without epithelial cells on the tumor surface or the residual ovarian surface | ✓ | |
A predominantly cystic gross appearance with only few solid necrotic or hemorrhagic areas | ✓ | ✓ |
Grossly mucinous cyst contents | ✓ | ✓ |
Areas of a cribriform, villous, or solid growth | ✓ | ✓ |
Microscopic mucin extravasation into the stroma | ✓ | ✓ |
Benign or borderline-appearing areas (either with atypia only or with intraepithelial carcinoma) | ✓ | ✓ |
Focal endometrioid-like appearance | ✓ | ✓ |
Microscopic cysts, generally > 2 mm | ✓ | ✓ |
"Expansile" invasive pattern (sharply demarcated, multicystic or labyrinthine spaces lined by malignant-appearing epithelial cells, with minimal or no recognizable intervening stroma, in an area exceeding 10 mm and at least 3 mm in any single dimension) | ✓ | |
A complex papillary epithelial growth (branching papillae with epithelial stratification and little or no stromal support) | ✓ | |
Intraluminal necrotic material (tumor cell karyorrhectic nuclear fragments, neutrophils, and acellular debris) in gland-cyst lumens | ✓ | |
Immunohistochemistry | ||
CK-7 | ✓ | ✓ |
CK-20 | ✓ | ✓ |
Dpc4 | ✓ | ✓ |